DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC6 and HDA1

DIOPT Version :10

Sequence 1:XP_047297659.1 Gene:HDAC6 / 10013 HGNCID:14064 Length:1261 Species:Homo sapiens
Sequence 2:NP_014377.1 Gene:HDA1 / 855710 SGDID:S000004966 Length:706 Species:Saccharomyces cerevisiae


Alignment Length:515 Identity:183/515 - (35%)
Similarity:273/515 - (53%) Gaps:54/515 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   482 EVLVRSTETVER---DNMEEDNVEESEEEGPWE---PPVLPILTWPVLQSRTGLVYDQNMMNHCN 540
            |||......::|   :|.||:|...:..:...:   |..:|.:.:..|  :|||.||..|..|..
Yeast     9 EVLENPDHDLKRKLEENKEEENSLSTTSKSKRQVIVPVCMPKIHYSPL--KTGLCYDVRMRYHAK 71

Human   541 LWDSH------HPEVPQRILRIMCRLEELG------------LAGRCLTLTPRPATEAELLTCHS 587
            ::.|:      |||.|:||.||...|.|.|            |....|.:..|.||..|:|..|:
Yeast    72 IFTSYFEYIDPHPEDPRRIYRIYKILAENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHT 136

Human   588 AEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVR 652
            .|::..:.:||||...||.:|:...||:|....::|.|:|..|.|....:||:.|.|.|..||||
Yeast   137 KEHLEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVR 201

Human   653 PPGHHAEQDAACGFCFFNSVAVAARH-AQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVS 716
            |||||||..||.|||.|::|||||:: .:.......||:|:|||:|||||||..|..|..|||||
Yeast   202 PPGHHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVS 266

Human   717 LHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELV 781
            |||::.|.::|...:|...|.|...|.||..|:.|....:|||:|:.|:.::|:|:..||.|:||
Yeast   267 LHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMWAFEQVVMPMGREFKPDLV 331

Human   782 LVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG 846
            ::|:|||||.||.:|.|.|:|..|.|:||:|..||.|.:.::|||||||.:|:.|..:..:.|:|
Yeast   332 IISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVVLEGGYNLDAIARSALSVAKVLIG 396

Human   847 DPPPLLTLPRP---PLSGALASITETIQVHRRYWRSLRVMKVEDREG-----PSSSKLVTKKAPQ 903
            :||.  .||.|   |....:..|.:.|::..:||...|  :.....|     |.:..:::|..| 
Yeast   397 EPPD--ELPDPLSDPKPEVIEMIDKVIRLQSKYWNCFR--RRHANSGCNFNEPINDSIISKNFP- 456

Human   904 PAKPRLAERMTTREKKVLEAGMGKVT----SASFGEES---TPGQTNSETAVVAL--TQD 954
                 |.:.:..:::..|......||    |....:.:   ||..:.|.|.::.:  |.|
Yeast   457 -----LQKAIRQQQQHYLSDEFNFVTLPLVSMDLPDNTVLCTPNISESNTIIIVVHDTSD 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC6XP_047297659.1 HDAC6-dom1 145..481 CDD:212545
HDAC6-dom2 531..881 CDD:212527 153/371 (41%)
zf-UBP 1179..1241 CDD:460464
HDA1NP_014377.1 HDAC_Clr3 81..403 CDD:212542 140/323 (43%)
Arb2 457..698 CDD:401634 11/55 (20%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.