Protein Alignment HDAC6 and HDAC3

DIOPT Version :10

• Sequence 1: XP_047297659.1
• Gene: HDAC6 / 10013
• HGNCID: 14064
• Length: 1261
• Species: Homo sapiens
• Sequence 2: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 349
• Identity: 86/349 - (24%)
• Similarity: 144/349 - (41%)
• Gaps: 59/349 - (16%)

Human   526 RTGLVYDQNMMN-HCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAE 589
            |....|:.::.| |   :.:.||..|||:......:...||..:.....|..|:..::|..||.|
  Fly     5 RVSYFYNADVGNFH---YGAGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDE 66

Human   590 YVGHLRATEKMKTRELHRESSNFDSIYICPSTFAC---------AQLATGAACRLVE------AV 639
            |:.:|:                    .:.|....|         |..:.|..|.:.:      |:
  Fly    67 YIAYLQ--------------------QVTPQNIQCNSVAYTKYLAHFSVGEDCPVFDGLFDFCAM 111

Human   640 LSGEVLNGA---------AVVRPPG--HHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVD 693
            .:|..|.||         ..:...|  |||::..|.|||:.|.:.:..  .:.:..|. |:|.:|
  Fly   112 YTGASLEGAQKLNHNHSDICINWSGGLHHAKKFEASGFCYVNDIVIGI--LELLKYHP-RVLYID 173

Human   694 WDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGD 758
            .|||||:|.|..|.....|:..|.|:|.: .|||  ..|...:||..:|..::|||... ..:.|
  Fly   174 IDVHHGDGVQEAFYLTDRVMTASFHKYGN-YFFP--GTGDMYEIGAESGRYYSVNVPLK-EGIDD 234

Human   759 ADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILI 823
            ..|...:..::..|...:.|..:::..|.|:..||.||...:|.:|:......:..| :...:::
  Fly   235 QSYFQVFKPIISAIMDFYRPTAIVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKEL-NVPTLVV 298

Human   824 LEGGYNLTSISESMAACTRSLLGD 847
            ..|||.|.:::......| |||.|
  Fly   299 GGGGYTLRNVARCWTHET-SLLVD 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	XP_047297659.1	HDAC6-dom1	145..481	CDD:212545
		HDAC6-dom2	531..881	CDD:212527	85/344 (25%)
		zf-UBP	1179..1241	CDD:460464
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	86/349 (25%)