Protein Alignment HDAC6 and HDAC11

DIOPT Version :10

• Sequence 1: XP_047297659.1
• Gene: HDAC6 / 10013
• HGNCID: 14064
• Length: 1261
• Species: Homo sapiens
• Sequence 2: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Alignment Length: 321
• Identity: 85/321 - (26%)
• Similarity: 139/321 - (43%)
• Gaps: 56/321 - (17%)

Human   154 GPERLH---AIKEQLIQEGLLDRCVSFQ---ARFAE-----KEELMLVHSLEYIDLMETTQYMNE 207
            |.||||   |.|.:.|.:.|   |...|   ..|.|     |::|..:|:.||:..:..:  ||.
  Fly    46 GLERLHPFDAAKGKHIHKLL---CAQLQLDDGSFYEPTELTKDQLRRIHTREYLKSLRWS--MNV 105

Human   208 ---GELRVLA---DTY-DSVYLHPNSYSCACLASGSVL--RLVDAVLGAEIRNGMAIIRPPG-HH 262
               .|:.::|   :.| ...||.|..:.    |:||:|  :|.       :..|.||....| ||
  Fly   106 ACIAEVPLMAFVPNRYIQRSYLRPMRFQ----AAGSILAGKLA-------LDYGWAINLGGGFHH 159

Human   263 AQHSLMDGYCMFNHVA--VAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYE 325
            .......|:|.:..::  :...:.|:..|:||::|||.|.|.|.|.:..|:...:|..|.::
  Fly   160 CCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMY--- 221

Human   326 QGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAG 390
            ....:|....:..|.....:.:.||          .|..|:......|:....||:|.:|:..||
  Fly   222 NAFVYPRDHVAKESIRCAVELRNYT----------EDGFYLRQLKRCLMQSLAEFRPDMVVYNAG 276

Human   391 FDALQGDPKGEMAATPAGFAQLTHLLMG---LAGGKLILSLEGGYNLRALAEGVSASLHTL 448
            .|.|:|||.|.:|.:..|..:...|:..   ..|..:::.|.||| |:|.|..::.|:..|
  Fly   277 TDVLEGDPLGNLAISAEGVIERDRLVFSTFRALGIPVVMLLSGGY-LKASAGVITDSIVNL 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	XP_047297659.1	HDAC6-dom1	145..481	CDD:212545	85/321 (26%)
		HDAC6-dom2	531..881	CDD:212527
		zf-UBP	1179..1241	CDD:460464
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	80/314 (25%)