Protein Alignment HDAC6 and hda-6

DIOPT Version :10

• Sequence 1: XP_047297659.1
• Gene: HDAC6 / 10013
• HGNCID: 14064
• Length: 1261
• Species: Homo sapiens
• Sequence 2: NP_001122780.1
• Gene: hda-6 / 177316
• WormBaseID: WBGene00018319
• Length: 957
• Species: Caenorhabditis elegans
• Alignment Length: 1166
• Identity: 372/1166 - (31%)
• Similarity: 527/1166 - (45%)
• Gaps: 303/1166 - (25%)

Human   152 PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKE--ELMLVHSLEYI-DLMETTQYMNEGELRVL 213
            ||..:|:..|||.|.:..:|::| :....|.|.:  :|.:.|....: ||||:.:...| ::...
 Worm    35 PESSDRILKIKEALTKTKILEKC-TVLTNFLEIDDADLEVTHDKSMVKDLMESEKKTQE-DINSQ 97

Human   214 ADTYDSVYL--HPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNH 276
            .:.||||::  ..||...|......|..|.:.::..|..||.|::|||||||......|:|:||:
 Worm    98 CEKYDSVFMTEFQNSMKVAKDGVACVRDLTNRIMANEASNGFAVVRPPGHHADSVSPCGFCLFNN 162

Human   277 VAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTT 341
            ||.||..|... ...|:||||.|||||.|||..|..|..||||||||:|.|.|||||..|::...
 Worm   163 VAQAAEEAFFS-GAERILIVDLDVHHGHGTQRIFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHI 226

Human   342 GFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATP 406
            |.|:|.||..|:..|:.|..|:||::...|||||:|.:|.|..|:::||||||.|||.|.|..||
 Worm   227 GSGKGLGYNANLALNETGCTDSDYLSIIFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTP 291

Human   407 AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVS 471
            .|::.:.:.|..||.|::::.||||||.:..|..|...:..|||.....:|...||..|...|..
 Worm   292 DGYSHILYHLKSLAQGRMLVVLEGGYNHQISAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCV 356

Human   472 CALEALEPFW--------------------------------------EVL---VRSTETVERDN 495
            ..:..|...|                                      |::   :.|||....|.
 Worm   357 SLVSVLRHHWNCFDYFPSRTSLRLAQWPIVNTKVIYNYDPTTRRADTGEIIQDELASTEFTASDV 421

Human   496 MEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRL 560
            :..:|:|                        |.:.:::....|.:|.:.:|||.|.|..||:..|
 Worm   422 IPTENME------------------------TLIYFNEGDDAHFDLEEDNHPEKPARTRRILKTL 462

Human   561 EELGLAGRCLTLT-PRPATEAELLTCHSAEYVGHLRATEKMKTRELHRES-SNFDSIYICPSTFA 623
            .|.|:..:|:... .|.||..|:...|:.:.:.|||.||.||..||..|: ..|:|||:...|..
 Worm   463 RESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMKDEELMEEAEKEFNSIYLTRDTLK 527

Human   624 CAQLATGAACRLVEAVLSGEV--LNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHA 686
            .|:.|.||..:.|:.:...:.  .|...:||||||||....:.|||.||:|||||::||. ...|
 Worm   528 VARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPGHHASASKSSGFCIFNNVAVAAKYAQR-RHKA 591

Human   687 LRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAW 751
            .|:||:|||||||||||.:|.:|.:|:|:|:||:|.|.|:|:|:....|.:|..||.|.:|||.:
 Worm   592 KRVLILDWDVHHGNGTQEIFYEDSNVMYMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPF 656

Human   752 NGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLA 816
            :|.:|||.:|..|:.|:::||||:|||:|||:|||||||..||||..:|:||.:|.:|:.|..||
 Worm   657 SGVQMGDNEYQMAFQRVIMPIAYQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLA 721

Human   817 SGRIILILEGGYNLTSISES-MAAC----TRSLL----GDPPPLLTLPRPPLSGALASITETIQV 872
            .||||.:|||||||||||.| .|.|    .||:|    .:.....|.|:...|..:.:|.|...|
 Worm   722 GGRIITVLEGGYNLTSISNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAV 786

Human   873 HRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEES 937
            .::||..|:..                                           :||.:::|.:
 Worm   787 QQKYWSILKGF-------------------------------------------QVTPSNYGLD- 807

Human   938 TPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEET 1002
                                                                             
 Worm   808 ----------------------------------------------------------------- 807

Human  1003 VGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQT 1067
                |.|:...:|::..|                              ||
 Worm   808 ----IDDEAYDDDSIDMA------------------------------DQ--------------- 823

Human  1068 PLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDM 1132
                                                  |.|.|:|.|......||
 Worm   824 --------------------------------------SSSSGSSSSSTRPSHNL---------- 840

Human  1133 ADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQV 1197
                      .:.|....:||.||..||||..|.|:|.|.::....|.:|....|.|.||:||:.
 Worm   841 ----------EIMDSGPAHAVVPLATCPHLKEVKPLPPAKINARTACSECQIGAEVWTCLTCYKY 895

Human  1198 YCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMP 1258
            .|||::|.|.:.||.:|.||:.||..|||.|||.|.:|||:.||:..|:.||::||||.||
 Worm   896 NCGRFVNEHAMMHHLSSSHPMALSMADLSVWCYPCDSYVHNPALIGAKSAAHESKFGETMP 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	XP_047297659.1	HDAC6-dom1	145..481	CDD:212545	133/333 (40%)
		HDAC6-dom2	531..881	CDD:212527	159/362 (44%)
		zf-UBP	1179..1241	CDD:460464	30/61 (49%)
hda-6	NP_001122780.1	Arginase_HDAC	32..366	CDD:450134	133/333 (40%)
		Arginase_HDAC	440..795	CDD:450134	159/355 (45%)
		zf-UBP	877..939	CDD:460464	30/61 (49%)