Protein Alignment HDAC6 and Hdac6

DIOPT Version :10

• Sequence 1: XP_047297659.1
• Gene: HDAC6 / 10013
• HGNCID: 14064
• Length: 1261
• Species: Homo sapiens
• Sequence 2: NP_001398533.1
• Gene: Hdac6 / 15185
• MGIID: 1333752
• Length: 1161
• Species: Mus musculus
• Alignment Length: 1193
• Identity: 891/1193 - (74%)
• Similarity: 960/1193 - (80%)
• Gaps: 66/1193 - (5%)

Human    47 MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEE 111
            |||||||| :||||:||.|||||.|:||.|.||..||.|||.|.|||||||||||||||.|..||
Mouse     1 MTSTGQDS-STRQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNLAEVKKKGKMKKLSQPAEE 64

Human   112 DLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVS 176
            ||:|||||:|||.|.....|||||.|||||:|||||||||||.|||||||:||||.||||.||||
Mouse    65 DLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPESPERLHAIREQLILEGLLGRCVS 129

Human   177 FQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLV 241
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||:|||||||
Mouse   130 FQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYDSVYLHPNSYSCACLATGSVLRLV 194

Human   242 DAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGT 306
            ||::|||||||||:||||||||||:||||||||||:||||||||:||||:|||||||||||||||
Mouse   195 DALMGAEIRNGMAVIRPPGHHAQHNLMDGYCMFNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGT 259

Human   307 QFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLH 371
            ||.||||||||||||||||.||||||||||||||.||||||||||||||||.|||||||||||||
Mouse   260 QFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLH 324

Human   372 VLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRA 436
            :|||||.||||||||||||||||.|||||||||||||||.|||||||||||||||||||||||||
Mouse   325 ILLPVASEFQPQLVLVAAGFDALHGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRA 389

Human   437 LAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNV 501
            ||:|||||||||||||||||||...||.|||.|:.|.|||||||||||.||.||.|.|.:||..:
Mouse   390 LAKGVSASLHTLLGDPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQEEDEVEEAVL 454

Human   502 EESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLA 566
            ||.||||.||...||:.|||:||:|||||||:.||:||||||:||||.|||||||||.|||:|||
Mouse   455 EEEEEEGGWEATALPMDTWPLLQNRTGLVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLA 519

Human   567 GRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGA 631
            .|||.|..|||.::|||||||||||.|||.|||||||:||||.:|||||||||||||||:|||||
Mouse   520 ARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYICPSTFACAKLATGA 584

Human   632 ACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDV 696
            ||||||||||||||||.|||||||||||.:|||||||||||||||||||.|:|.|||||||||||
Mouse   585 ACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAARHAQIIAGRALRILIVDWDV 649

Human   697 HHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADY 761
            ||||||||:||||||||||||||||.||||||||||||||:||.||.||||||.|||||||||||
Mouse   650 HHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADY 714

Human   762 LAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEG 826
            |||||||||||||||||||||:|||||||:|||||||||:|||||||||||||||.|||||||||
Mouse   715 LAAWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEG 779

Human   827 GYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGP 891
            ||||.||||||||||.||||||||.|||.|||.||||.||:|.|||||:||||||:||:||:|..
Mouse   780 GYNLASISESMAACTHSLLGDPPPQLTLLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEEC 844

Human   892 SSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQP 956
            |||:||.||.|..|.|..|:.|||.:.||.|..:.|..:|..|:|||.||..|:.|...|.|.|.
Mouse   845 SSSRLVIKKLPPTASPVSAKEMTTPKGKVPEESVRKTIAALPGKESTLGQAKSKMAKAVLAQGQS 909

Human   957 SEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGAT 1021
            ||.|..|.||                            |..||:||||||..|
Mouse   910 SEQAAKGTTL----------------------------DLATSKETVGGATTD------------ 934

Human  1022 LGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGT 1086
                            ...|.||.|... :||||.||.|.||  .||.||.|:.||...||:||.
Mouse   935 ----------------LWASAAAPENFP-NQTTSVEALGETE--PTPPASHTNKQTTGASPLQGV 980

Human  1087 TPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFY 1151
            |.|  .|..:|.|.||||..|::.|.:|    ||.|||||||||||...||.||......|.:||
Mouse   981 TAQ--QSLQLGVLSTLELSREAEEAHDS----EEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFY 1039

Human  1152 AVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGH 1216
            |||||.|||||:||||||||||||:|||..|||:|||||||:||||||.||:|.||:.||..|.|
Mouse  1040 AVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCSRYVNAHMVCHHEASEH 1104

Human  1217 PLVLSYIDLSAWCYYCQAYVHHQ 1239
            |||||.:|||.|||.|||||||:
Mouse  1105 PLVLSCVDLSTWCYVCQAYVHHE 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	XP_047297659.1	HDAC6-dom1	145..481	CDD:212545	305/335 (91%)
		HDAC6-dom2	531..881	CDD:212527	304/349 (87%)
		zf-UBP	1179..1241	CDD:460464	44/61 (72%)
Hdac6	NP_001398533.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..61		46/60 (77%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:10873806	66..75		6/8 (75%)
		Histone deacetylase 1	87..403		291/315 (92%)
		Arginase_HDAC	98..434	CDD:450134	305/335 (91%)
		Histone deacetylase 2	481..799		279/317 (88%)
		HDAC6-dom2	484..834	CDD:212527	304/349 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	954..975		11/22 (50%)
		zf-UBP	1067..1128	CDD:460464	44/61 (72%)
		Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7	1088..1090		0/1 (0%)
		Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7	1116..1123		5/6 (83%)