Protein Alignment HDAC6 and hdac6

DIOPT Version :10

• Sequence 1: XP_047297659.1
• Gene: HDAC6 / 10013
• HGNCID: 14064
• Length: 1261
• Species: Homo sapiens
• Sequence 2: XP_031746852.1
• Gene: hdac6 / 100379853
• XenbaseID: XB-GENE-5873935
• Length: 1056
• Species: Xenopus tropicalis
• Alignment Length: 1236
• Identity: 490/1236 - (39%)
• Similarity: 635/1236 - (51%)
• Gaps: 249/1236 - (20%)

Human    43 ASSTMTST--GQDSTTTRQRR-----SRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKG 100
            |.|.|.|:  .|.|.|.|..|     ||:.|:              :|||.|:...:|.::||:|
 Frog     7 AQSCMASSAGAQTSGTPRGMRGSLPLSRKAPR--------------RKGASPQGSQSLRKLKKRG 57

Human   101 --KMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKE 163
              :|::...........|..|...... :|:.|||||.|||:.:..| ||::|||.|.|:.|:::
 Frog    58 AHRMRRTRPRRSCVTTRGTGGEPYKAR-QAVQGTGLVYDEQMAQTCCXWDENFPECPARIWAVRD 121

Human   164 QLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYS 228
            ::.:.||.:|||:.|||.|.:||:.|:||.:|:.||.:||.||..||:.|:|.||||||||.|::
 Frog   122 KMAEYGLAERCVAVQAREASEEEISLIHSPQYVALMGSTQNMNVEELQALSDRYDSVYLHPTSFT 186

Human   229 CACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRV 293
            ||.||.||||:|||.||..|||||:|::|||||||....|:||||||.:|:||||||:.:..:||
 Frog   187 CASLAVGSVLQLVDKVLRREIRNGLAVVRPPGHHAHVDQMNGYCMFNQLAIAARYAQRTYGAKRV 251

Human   294 LIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQV 358
            |||||||||||||||.|:.||||||||:||||.|.|||||:.|..|..|..:|:.:.:||.||:.
 Frog   252 LIVDWDVHHGQGTQFLFENDPSVLYFSVHRYENGGFWPHLRESASSAVGKERGERFNVNVAWNKT 316

Human   359 GMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGK 423
            .|.|||||..||::|||:|.||||.|||||||||::.|||||||:|||..|:.||||||.||.|:
 Frog   317 RMSDADYIHVFLNILLPIAYEFQPHLVLVAAGFDSVVGDPKGEMSATPGCFSHLTHLLMSLAQGR 381

Human   424 LILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRST 488
            ||||||||||.|:|||||.|.|..|||||||.|..|.|||:||..|:|..|.|....|:|| :..
 Frog   382 LILSLEGGYNQRSLAEGVCACLKALLGDPCPKLPLPSAPCQSALDSISDTLSAHCRLWKVL-QDY 445

Human   489 ETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQ-------SRTGLVYDQNMMNHCNLWDSHH 546
            |:......|..:.||...:|..|||:..:|...:::       .||.||||:.||.|.|:|||.|
 Frog   446 ESEGEAIDEPQSAEEQPPDGADEPPLEKVLEQSMMEVMREVPAQRTALVYDEQMMEHHNMWDSCH 510

Human   547 PEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSA-EYVGHLRATEKMKTRELHRESS 610
            ||.||||.:|..|.::|||..||..:.........|..|... .|:..:.|:.. ..|.. ....
 Frog   511 PESPQRINQIFKRHKDLGLLDRCSRIPSALGHSEGLQMCTGGLSYIQKIEASATXTPRPA-PTGD 574

Human   611 NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVA 675
            .:: |||...::..|:||.|:...:||||::|:..||..:|||..|..:...||||||||:||..
 Frog   575 EYNXIYINSRSYHSARLAAGSTFSVVEAVVTGKAQNGVCIVRPGSHMQKPAEACGFCFFNTVAQP 639

Human   676 ARHAQTISGHA---LRILIVDWDVHHGNGTQHMFEDDPS-VLYVSLHRYDHGTFFPMGDEGASSQ 736
            ||:||.:...    ||::|:|| |||||||||:|:..|. ||||||||||.|.|||..:|...::
 Frog   640 ARYAQRLRSRXEDPLRVMILDWXVHHGNGTQHIFQRMPGCVLYVSLHRYDEGLFFPNSEEHHMTR 704

Human   737 IGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVS 801
            .....|.|...|:.|||.: ||.:.|.|:||:|:|||||.......: ||||...|||||.|: |
 Frog   705 FAIGKGAGSMWNIPWNGSKXGDPEILMAFHRVVMPIAYELTRSWFCI-AGFDGPAGDPLGACKXS 768

Human   802 PEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASI 866
            |||.| |||||||||.||:||:||||||...||||.........|||||.|:..|||...|..|:
 Frog   769 PEGNAXLTHLLMGLAGGRVILVLEGGYNQHPISESHGYVHSLPSGDPPPTLSDLRPPKPSAFNSV 833

Human   867 TETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQ-------------PAKPRLAERMTTREK 918
            .:..|.||:..||||:                ..|||             |.|.|.|
 Frog   834 RKVRQAHRQVGRSLRL----------------NVAPQGAHNLQHSPVMXNPQKGRFA-------- 874

Human   919 KVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQT 983
              .|||...:.|..       |.|:.:.   .|.:|:.|                      |.:.
 Frog   875 --TEAGPSAMISHK-------GLTSQQD---PLRRDRHS----------------------LHRH 905

Human   984 TSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGA 1048
            :::.:| ..||.....|    ...|.:.......|.|..|
 Frog   906 SAQTSV-AETPRPLVPE----SRFLPRGGDPHKAGAAGRG------------------------- 940

Human  1049 TLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASE 1113
                      .||:|                     ..||.|...||:.|:           |:|
 Frog   941 ----------CGGSE---------------------AETPTIGFETLMESM-----------ANE 963

Human  1114 SQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIP-----AAGL 1173
            |              |:|                    .:||||..|..:..|..|     |.|.
 Frog   964 S--------------GED--------------------CITPLPGAPTWLCECCAPGGSGCAVGR 994

Human  1174 DVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHH 1238
            .|:.      |....|.|                |.||      ||..:.|||.|||.|::||||
 Frog   995 YVSP------THAVPWTC----------------LWHH------LVSQFSDLSVWCYGCESYVHH 1031

Human  1239 Q 1239
            |
 Frog  1032 Q 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC6	XP_047297659.1	HDAC6-dom1	145..481	CDD:212545	208/335 (62%)
		HDAC6-dom2	531..881	CDD:212527	163/354 (46%)
		zf-UBP	1179..1241	CDD:460464	20/61 (33%)
hdac6	XP_031746852.1	Arginase_HDAC	103..439	CDD:450134	208/335 (62%)
		Arginase_HDAC	495..848	CDD:450134	163/354 (46%)
		zf-UBP	978..1033	CDD:460464	25/83 (30%)