Protein Alignment pi4ka and Pi4KIIIalpha

DIOPT Version :9

• Sequence 1: XP_031761716.1
• Gene: pi4ka / 100127709
• XenbaseID: XB-GENE-980714
• Length: 2102
• Species: Xenopus tropicalis
• Sequence 2: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Alignment Length: 2228
• Identity: 998/2228 - (44%)
• Similarity: 1373/2228 - (61%)
• Gaps: 223/2228 - (10%)

 Frog    14 YFNTVLSLARSLAVQRPAAFEKVQKLLCMCPVD-YHGVFQLDERRRDALIALGIFLVESDLQHKE 77
            |..|||.|||.||..:|..::|||.|...||.: ..|||.||.|.:||:|||||:.:|...||:.
  Fly    11 YQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEG 75

 Frog    78 TVVPYLLRLLRGLPKVQWIEESNSRK-GKGTLPVAETFSFCLVTLLSDVAHRDLSFREQILEAVL 141
            .:|||||||.:.|||..||:::.|.| .:..:|.||.|||||.|||||:|.:....||:|:...:
  Fly    76 QIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQV 140

 Frog   142 DVMQCLLGMCQS--------PQIQDKEYLCKYAVPCLIGISRAFGRYSNTEESLLSKLFPKVSPQ 198
            :.:..|..:.:|        |.|    .|||..||.|.|::|:.|||::.:..||.::||   |:
  Fly   141 ETLSALANIVKSSRDSSSAPPPI----ILCKATVPLLFGLARSMGRYASNDPPLLCRIFP---PE 198

 Frog   199 SLK-----------APEELEGIRRRSFND---------FRSILPSSLLTVCQGDSLKRKASSVSS 243
            .|.           :.....|....||:.         ||.|:|.|:    .|...:.:.:|...
  Fly   199 LLPIQKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSM----SGSLAQAQNASYDD 259

 Frog   244 GSQVSPDRIVPPPGSPAGSTI-PYFEGSYLPDGSAVDP-DYYLTTISSSFSVSPLFTGVNNKEFD 306
            |.|....      |.|:..:: .||...|       || .::.|...|||:..|     |.:..:
  Fly   260 GRQRCAG------GKPSKPSLHSYFSVPY-------DPRTHFFTRYGSSFNQFP-----NMRVCE 306

 Frog   307 MPQ---------------DTLRQLLHMVKQIVADPFLSSLDMLISEVTEANPSVDLYYKTFSDPL 356
            .|.               ..|:.:..:.|:::....|..||...|::...:......||:||:.|
  Fly   307 SPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETL 371

 Frog   357 YVAVFKMLRDTLYNVKDPHTSFVKEIHDFVLEQFNSSQGELQKILHDMDRLNNE------LSPLK 415
            .:.:..:||:.|.:..|..|.|.|::.:||...|.:.|.|||....|.:|...|      ::..|
  Fly   372 NLVLVTLLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYK 436

 Frog   416 LRCQANAACVDLMVWAVKDE--------------------QGAENLCIKLSEKLQSKTSSKVIIA 460
            :...||||||||:|||::||                    :.|:.||.:||:||..:.|.|:::.
  Fly   437 VNVMANAACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMD 501

 Frog   461 HMPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQ------YQTGANDIK 519
            |||||:.||:|||:|..:||.:..:....||||||.|||:|.||:.:..|      .:......|
  Fly   502 HMPLLMVCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFK 566

 Frog   520 ISVTNEHSESTMNIM------------SGKKSQASMYEQLRDIAIDNICRCLKAGLTIDPVIVEA 572
            |:|  :||:|...::            :|:...|: :|.|||.||:|:...|:|..|:|...|.|
  Fly   567 IAV--QHSDSRTAVVIYGDNQKPPGSGTGRSGHAA-FESLRDAAIENLSIALRAAHTLDQFCVPA 628

 Frog   573 FLASLSNRLYISQ----ENEKDAH---LIPDHTIRALGHIAVALRDTPKVMQPILQILQQKFCQP 630
            .:|::||||:.::    |::.:.|   |:..:.|..|||:||||:||.|..|.|||...|:||:.
  Fly   629 LVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKV 693

 Frog   631 PSQLDVLIIDQLGCMVITG-NQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINA 694
            ||:.:.||:||||||:|:. ..:::.|:..:|.:::|:::|:.|::..:::.. :.|.|.||:||
  Fly   694 PSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQ-FHHVSDAVVNA 757

 Frog   695 LANIAANIQGEHQIDDLLMNLLELFVQLGLEGKRASERASEKGP-ALKASSSAGNLGVLIPVIAV 758
            |.||||||||:.::.:||..|||||||:||:|    ||:.:..| |.||||.|||||:|||||||
  Fly   758 LGNIAANIQGDAEMLELLGKLLELFVQIGLDG----ERSYDNTPGAQKASSRAGNLGMLIPVIAV 818

 Frog   759 LTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPS--KE 821
            |.|||||||..:.||.|||:|||.|.|:|||.  .:.|||.:||:||.:||.|||||...:  |.
  Fly   819 LVRRLPPIKNPRQRLHKLFKDFWAYCVVMGFT--NARLWPADWYQGVQQIAAKSPLLISQTAHKS 881

 Frog   822 PLRSVLQYNSAMKNDTVTPAELNELRSTIINLLDPAPE-VSALINKLDFAMSTYLLSVYRLEHMR 885
            .:|. |.|..|:|:|:|     |||||.|:.||:.:.: |:..||||.||..|||||||.||.:|
  Fly   882 DMRE-LNYTLAIKSDSV-----NELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLR 940

 Frog   886 VLHATDKDRFQVMFFYFEDKAIQKDKSGMMQCVIAVADKVFEAFLNVMADKPKTKENEEELERHA 950
            |.:| |:...:.:..|..|.|:|:||:|:.|||..|||:|||.|.||:....:.:  |:.||..|
  Fly   941 VENA-DEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIR--EKVLESQA 1002

 Frog   951 QFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYD 1015
            ..|||.||||||.|:.|||:|||.|||:||||||:..||..||||||.|:.|||.|.:::.|...
  Fly  1003 TLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLR 1067

 Frog  1016 IPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPSVTKSHLQEYLNKHQNWMSGLSQHT 1080
            :...||.:.:.|:..|||..:||||.||..|:.|||||||..|:||||||.|:....:  |:.|:
  Fly  1068 VVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPV--LAHHS 1130

 Frog  1081 GLAMATESILHFAGYNRQNTTLGSPASSAQVT-QLTERPACVKKDYSNFMASLNLRNRYAGEVAG 1144
            |||:|.:|::               :||||.| .:::||:||..|...|::.|.||::||||::|
  Fly  1131 GLALAFDSVV---------------SSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISG 1180

 Frog  1145 MIEFSDATGRTSDLNRLMLKHLGDALD-CGQPES--YTQVMFKLTALLISSKECDAQLLHHLCWA 1206
            ::.......:....:||    :.|..: |.:...  :...:::.||.||...|...:|||.:..:
  Fly  1181 LLSVLSEKDKAGLADRL----VSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASS 1241

 Frog  1207 PLRMFTDHGMETAIACWDWLLAAKNGIEVPFMREMAGAWQMTVEQKIGLFSAEKKEADPLAASEQ 1271
            .|.:||:..||||:.||.|:|.|:..:|:.|::||..|||.|.|:::|||:.|.:...||||.|.
  Fly  1242 QLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEG 1306

 Frog  1272 SQ--PRPCAPQVNPHYIWIDFLMQRFEIAKYCSSDQVEIFSSLLQRSLSLNIGGCKGS-LNRHVA 1333
            .:  .:|..  :.||.||:..|.:..:.||||:.|:||:|..||.|.|.:    .|.| .||.|:
  Fly  1307 CKLVSKPIL--IAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPV----LKSSKQNRQVS 1365

 Frog  1334 AIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQTQKLLREDISIMIK 1398
            .:|.|||||..|||||..:.:|.:..||:|||:|||.|.|||..||..|.|:::.|.|||.|::|
  Fly  1366 TVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLK 1430

 Frog  1399 FWTAMFSDKKYLTANQLVPPDNQDPSVNSLSVM------------------SDVNRS-------- 1437
            ||..|.|:||:|..:::...|..:.||:|..::                  :|..||
  Fly  1431 FWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAV 1495

 Frog  1438 --NLDVTVGSRQQTAQGWINTYPLSSGMSTISKKSGLAKKTN-RGTQLHKYYMKRRTLLLSLLAT 1499
              .:.|..|.   ::.||.||.|.|:  ||:||:|..:|:.. :.....|.|||:|.|:|.|||.
  Fly  1496 GMGMGVAGGG---SSSGWYNTIPHST--STLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAV 1555

 Frog  1500 EIERLTTWYNPLSSPELELDQTGENSVANWRSKYISLSEKQWKDNVNLAWSISPHLALQLPTRFK 1564
            |:|.|.|||||.|.|:|.:  .||..:..||::  ......|:|...|||..:|.||:.||.|.|
  Fly  1556 ELEFLITWYNPNSLPDLIV--PGEEQITEWRNR--PYKSTVWRDYARLAWCYNPALAVFLPQRIK 1616

 Frog  1565 NTEAIGGEVTRLVRLDPGAVSDTPEAIKYLVTWHTIDADAPELSHILCWTPTDPPTGLSYFSSMY 1629
            |.|.|..||:|||..||.||...|||:|||.|...:..::|:|.:||.|:|..|...|:|||..|
  Fly  1617 NAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQY 1681

 Frog  1630 PPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKT 1694
            |.|||||||.||.|.|:|.:::|.||||:|||||:|.||||.|:|...:.:||::|||.||||:|
  Fly  1682 PSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQT 1746

 Frog  1695 NIFLDEEGHQKDPDIGELLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPFPKGEERK 1759
            |:::||:...|||::.|.|:||.:.|..|.||.||.||:||||||.|||.||..|:.|.||.|||
  Fly  1747 NMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERK 1811

 Frog  1760 KACLNSLSEVKVQPGCYLPSNPEAIVLDIDYTSGTPLQSAAKAPYLAKFKVKRCGVSELEKEGLS 1824
            .|||.:||.:|||.||||||||||:||||||:||||:||||||||||:|:|.|||::|||...:.
  Fly  1812 NACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAME 1876

 Frog  1825 CRSDSIDESEEEGGDGKVCWQAAIFKVGDDCRQDMLALQIIGLFKNIFQLVGLDLFVFPYRVVAT 1889
            ..::...:.:.:...|...|||||||||||.||||||||:|.:||||||.||||||:||||||||
  Fly  1877 VSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVAT 1941

 Frog  1890 APGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESALAFQKARYNFIRSMAAYSLLLFLLQ 1954
            |||||||||:|:..||||||||||.|:.:||..||||||:..||.||.||::|||||||:.:|||
  Fly  1942 APGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQ 2006

 Frog  1955 IKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEM 2019
            ||||||||||:||.|||||||||||||||||||:|:|||:||||||||||||||::..||||.|:
  Fly  2007 IKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCEL 2071

 Frog  2020 CVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKQRFSPNSTEREAANFILKVIQNCFLS 2084
            ||:.:||||||.||:||||:|||||||||||||||.||||||......:|||..:|.||:|.:.:
  Fly  2072 CVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQN 2136

 Frog  2085 NRSRTYDMIQYYQNDIPY 2102
            .|:|||||||||||.|||
  Fly  2137 FRTRTYDMIQYYQNQIPY 2154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pi4ka	XP_031761716.1	PI4Ka	1548..1723	CDD:238443	91/174 (52%)
		PI4Kc_III_alpha	1784..2101	CDD:270711	222/316 (70%)
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	91/174 (52%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	222/316 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1005	1.000	Domainoid score	I34
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11171
Inparanoid	1	1.050	1682	1.000	Inparanoid score	I72
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	1	1.000	-	-		FOG0002854
OrthoInspector	1	1.000	-	-		oto104000
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160