DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf145l and JHD2

DIOPT Version :9

Sequence 1:	NP_001106467.1	Gene:	rnf145l / 100127651	XenbaseID:	XB-GENE-5921670	Length:	679	Species:	Xenopus tropicalis
Sequence 2:	NP_012653.1	Gene:	JHD2 / 853583	SGDID:	S000003880	Length:	728	Species:	Saccharomyces cerevisiae

Alignment Length:	736	Identity:	128/736 - (17%)
Similarity:	234/736 - (31%)	Gaps:	267/736 - (36%)

- Green bases have known domain annotations that are detailed below.

Frog     4 LEEIANVVLRLPSVVV--------LDLLYR--WDFQAFTELSRP----TYETNFFKSKY------ 48
            :::.:.::||.|..:|        .::|.:  :.:..|:||.:.    |..|..|:.|.
Yeast    88 VKDPSKLILREPYTIVEYSDSTHASEILKKKVYFYDVFSELIKDNRTLTDTTQSFRRKLKFRDIS 152

Frog    49 -------LW-NIYYLAHVLCAVLLLLPLRYLVSIYLYLLTALLLYVGHQTTRDYIHQEMDSD-FP 104
                   || .|....:|...:|..:..:|:.|.|::|          .:..:.:|..:.:| :|
Yeast   153 QLRGDISLWRTISKKFNVPIGLLKEIFEKYIASYYIFL----------HSLNENVHTALHADQYP 207

Frog   105 -------------------GALFEDQGALSRIITALTGLVIVGTLCSLLMKTRHAWLFC-SPVLP 149
                               |:.||:....:.|:...|.......||....|..|  ::| ||
Yeast   208 KSLLSDDEDDFDLGPDSNSGSDFEEDDDDACIVCRKTNDPKRTILCDSCDKPFH--IYCLSP--- 267

Frog   150 LLGRIVGLPLQALPPLNNFSIFLTVLGSLFYVLS------NLGVLLILFRKVYQEIVQVQELDRV 208
                    ||:.:|. .::.....::|:.:|..:      :|        ..:||..:.|....:
Yeast   268 --------PLERVPS-GDWICNTCIVGNGYYGFTQDTHDYSL--------PEFQEYCKRQNSRLL 315

Frog   209 VALVMQLWTHLAVPLLFLVFWLVSFSFHIVSFLSSKPGA----------LGQQGLIFIFLN---- 259
            .|      ..|::..|..:||.:.......|..:.|.||          .|.....||..|
Yeast   316 PA------RKLSIDELEEMFWSLVTKNRRSSLTTVKYGADIHNELPGQITGFPTREFIPKNINGD 374

Frog   260 ---SAAECCGTPYCLIGLT----------------FTVSYLALGML--NFC----KFYLLGFDAF 299
               ...:.|..|..|..|.                .|:.::.:|.|  .||    ..|.|
Yeast   375 ELIDYLKYCDHPMNLTNLPMAHNSLLPLFKRNISGMTIPWIYIGSLFSTFCWHMEDQYTL----- 434

Frog   300 RNGNVMHRG-------VTE-GVTLMLLALQTGLLDLQVLQRTFLLSIILFIVVTSTLQSMIEIAD 356
             :.|..|.|       :.| |.|.....|.....||.:.|...|..::          ::|...|
Yeast   435 -SANYQHEGDPKVWYSIPESGCTKFNDLLNDMSPDLFIKQPDLLHQLV----------TLISPYD 488

Frog   357 PIVLALGATRNRSLWKHLRGVSMCLFLLVFP-CFMA-----YKISQF--FHMDFWL---LILVSS 410
            |.....|....:::.|...      :::.|| |:.|     |..::.  |.:||||   ...::.
Yeast   489 PNFKKSGIPVYKAVQKPNE------YIITFPKCYHAGFNTGYNFNEAVNFTIDFWLPYGFGAITD 547

Frog   411 CMLTSLQVLGTLFIYALFMVE-------LFHDSQVEKI--DEIIYYVNAVSRVLEFLVAVCVVAY 466
            ..||....:..:|...:.:::       ||:|:.|.:.  ..|::|...:.|:
Yeast   548 YKLTQKACVFDMFDLMINVLDKYNKDTLLFNDAFVRQCYSSLIVFYNTELKRI------------ 600

Frog   467 GTWESLFGEWSWMGVSVIIVHSYFNVWLRAQSGWKSFLLRREAAKKISSL-PMATLEQLRAHND- 529
                                                        :||.:: |..||  |..|.|
Yeast   601 --------------------------------------------RKIQAIVPRTTL--LEVHTDP 619

Frog   530 ----------------VCPICF---QDMSGAVITPCSHIFHGECLRKWLYVQDT----CPICHQQ 571
                            :|.|.|   ::...::.|...|..:...:|:|..:..|    ..:|.|.
Yeast   620 NDEDEEYDIFCSQCKTICSIAFVLRKNNYDSIRTYKRHKKNHLSIRQWNELSTTDSKVSILCTQD 684

Frog   572 VKPLAETLR--EGEEKSEEEE 590
            .....:.|.  :|||...::|
Yeast   685 YLKSIQNLNNSDGEEPYIDDE 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145l	NP_001106467.1	TRC8_N	5..500	CDD:290425	105/616 (17%)
		zf-rbx1	<528..569	CDD:289448	9/64 (14%)
		zf-RING_2	529..569	CDD:290367	9/63 (14%)
JHD2	NP_012653.1	JmjN	3..46	CDD:128818
		PHD_BAZ1A_like	237..282	CDD:277019	12/58 (21%)
		BAH	260..>320	CDD:413397	14/87 (16%)
		JmjC	414..532	CDD:396791	27/139 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910