DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf145l and Rnf145

DIOPT Version :9

Sequence 1:	NP_001106467.1	Gene:	rnf145l / 100127651	XenbaseID:	XB-GENE-5921670	Length:	679	Species:	Xenopus tropicalis
Sequence 2:	NP_001350095.1	Gene:	Rnf145 / 74315	MGIID:	1921565	Length:	663	Species:	Mus musculus

Alignment Length:	675	Identity:	349/675 - (51%)
Similarity:	465/675 - (68%)	Gaps:	34/675 - (5%)

- Green bases have known domain annotations that are detailed below.

Frog     3 RLEEIANVVLRLPSVVVLDLLYRWDFQA-FTELSRPTYETN-FFKSKYL-WNIYYLAHVLCAVLL 64
            :||.:.||.||:||:::||:|||||..: |.::.|.:...| .|:.||| .|::|:.::|..|||
Mouse     6 KLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLNNNPLFQYKYLALNMHYVGYILSVVLL 70

Frog    65 LLPLRYLVSIYLYLLTALLLYVGHQTTRDYIHQEMDSDFPGALFEDQGALSRIITALTGLVIVGT 129
            .||.::||.:|||.:||||||.|||.:|||:..|::|.:.|.::.:..:::|..|||.|.::|.|
Mouse    71 TLPRQHLVQLYLYFVTALLLYAGHQISRDYVRSELESAYEGPMYLEPLSMNRFTTALIGQLVVCT 135

Frog   130 LCSLLMKTRHAWLFCSPVLPLLGRIVGLPLQALPPLNNFSIFLTVLGSLFYVLSNLGVLLILFRK 194
            |||.:|||:..|||.:.:||||.|:..:||:.:..:|.|::..|.|..|:::.|||.|...|.:.
Mouse   136 LCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKS 200

Frog   195 VYQEIVQVQELDRVVALVMQLWTHLAVPLLFLVFWLVSFSFHIVSFLSSKPGALGQQGLIFIFLN 259
            .|:|:|||.|:..::||.|.||..|.||:||:|||||.|:..|.|:.|::.....::.|:|:||.
Mouse   201 AYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLT 265

Frog   260 SAAECCGTPYCLIGLTFTVSYLALGMLNFCKFYLLGFDAFRNGNVMHRGVTEGVTLMLLALQTGL 324
            |.||||.|||.|:||.||||::|||:|..|||||.|:.||.|...|:||:||||||::||:||||
Mouse   266 SIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGL 330

Frog   325 LDLQVLQRTFLLSIILFIVVTSTLQSMIEIADPIVLALGATRNRSLWKHLRGVSMCLFLLVFPCF 389
            ::|||:.|.|||||||||||.|.||||:||||||||||||:|::|||||.|.||:||||||||.:
Mouse   331 IELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAY 395

Frog   390 MAYKISQFFHMDFWLLILVSSCMLTSLQVLGTLFIYALFMVELFHDSQVEKIDEIIYYVNAVSRV 454
            |||.|.|||||||||||::||.:|||||||||||||.|||||.|....||.:|::|||||...|:
Mouse   396 MAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRL 460

Frog   455 LEFLVAVCVVAYGTWESLFGEWSWMGVSVIIVHSYFNVWLRAQSGWKSFLLRREAAKKISSLPMA 519
            |||:||:||||||..|::||||:.||..:|.:|||:|||||||.|||||||||:|..||.|||:|
Mouse   461 LEFVVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPVA 525

Frog   520 TLEQLRAHNDVCPICFQDMSGAVITPCSHIFHGECLRKWLYVQDTCPICHQQVKPLAETLREGEE 584
            |.|||..|||:|.||:|||..||||||||.||..||:||||||||||:||..:|..::....|.|
Mouse   526 TQEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHLKNSSQLPGLGTE 590

Frog   585 KSEE-----EEEVEADEEVRAEVTAHGFRRNQCNPERGREEMELGEDRRDQTNGGERRCDAKHER 644
            .:.:     |:.:...|                .||....|...|..  .|...|:       ..
Mouse   591 AAPQPPAGAEQNIVLQE----------------GPEPPDHESPPGTG--TQEGSGD-------SS 630

Frog   645 EEVEEEDEGENSASGGGEGSHL-EG 668
            |.:......:..|:..|||..: ||
Mouse   631 EHINRGSASQEGAADAGEGPQIPEG 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145l	NP_001106467.1	TRC8_N	5..500	CDD:290425	277/497 (56%)
		zf-rbx1	<528..569	CDD:289448	30/40 (75%)
		zf-RING_2	529..569	CDD:290367	29/39 (74%)
Rnf145	NP_001350095.1	TRC8_N	8..506	CDD:372682	277/497 (56%)
		YLYF motif. /evidence=ECO:0000269\|PubMed:29374057	81..84		2/2 (100%)
		HRD1	<520..627	CDD:227568	51/124 (41%)
		RING-H2_RNF145	533..575	CDD:319598	31/41 (76%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	28/36 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..663		17/94 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930