DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf145l and rnf-145

DIOPT Version :9

Sequence 1:	NP_001106467.1	Gene:	rnf145l / 100127651	XenbaseID:	XB-GENE-5921670	Length:	679	Species:	Xenopus tropicalis
Sequence 2:	NP_491382.2	Gene:	rnf-145 / 172053	WormBaseID:	WBGene00022471	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	194/713 - (27%)
Similarity:	333/713 - (46%)	Gaps:	79/713 - (11%)

- Green bases have known domain annotations that are detailed below.

Frog     3 RLEEIANVV----LRLPSVVVLDLLYRWDFQAFTELSR-------------PT-----YETNFFK 45
            :::|::.:|    ||||.::.::||:|:...:|.::|.             ||     :..||..
Worm    43 KIKEMSIMVLETGLRLPGLLFIELLWRYQGFSFEDISDDMMKQTPLSYFDIPTMLDFVHRRNFDH 107

Frog    46 SKYLWNIYYLAHVLCAVLLLLPLRYLVSIYLYLLTALLLYVGHQTTRDYIHQEMDSDFPGALFED 110
            ...:...|::..: ..:.|.|||..|:.:|.:.|:..|..|.::.:..|:..||.:.      |:
Worm   108 HAAIILSYFVIFI-SLMFLTLPLSRLIRMYSHFLSVFLFGVAYKLSAIYVDLEMKTG------EE 165

Frog   111 QGALSRIITA-------LTGLVIVGTLCSLLMKTRHAWLFCSPV--LPLLGRIVGLPLQALPPLN 166
            :..|..:|..       |..:::|.....||......|....||  ||::.|:.|.|:..|...:
Worm   166 ELKLDGLIKLERHGFHFLAQMLLVVLQSMLLEVDGEPWRVALPVFALPIVARMCGCPMDKLKNAH 230

Frog   167 NFSIFLTVLGSLFYVLSNLGVLLILFRKVYQEIVQVQELDRVVALVMQLWTHLAVPLLFLVFWLV 231
            |::...|::....|:|.....|:...:...::|..|..:..:...|..||..|.:..|....|:.
Worm   231 NYACTGTMIFIATYMLYRAPSLIKSTKTALRQIKAVFMVHGLADGVAVLWRKLRILELLTFTWIT 295

Frog   232 SFSFHIVSFLSSKPGALGQQGLIFIFLNSAAECCGTPYCLIGLTFTVSYLALGMLNFCKFYLLGF 296
            .|...:...|..|.....:.|.  |.|...||...||..|..|..:|||:...:.:..|....|.
Worm   296 MFLMVLYVELIDKGRTWSEVGR--ILLTGVAETTNTPITLAALAVSVSYVCKWIADLTKLITGGT 358

Frog   297 DAFRNGNVM-HRGVTEGVTLMLLALQTGLLDLQVLQRTFLLSIILFIVVTSTLQSMIEIADPIVL 360
            .:  :|:|: |.|.||.|::::|.:|||.|.:||.|:|.||:::|:||:::.|||:.||.:.::|
Worm   359 RS--HGHVLAHSGYTEAVSVVILCIQTGFLGMQVEQKTILLALVLYIVISALLQSLFEIIEVVLL 421

Frog   361 ALGATRNRSLWKHLRGVSMCLFLLVFPCFMAYKISQFFHMDFWLLILVSSCMLTSLQVLGTLFIY 425
            .|.::...|..:|.|.:.:.|.|:|.|.|....:.....:|.:..|::::....:.:.:|.:..|
Worm   422 NLPSSPTASRARHARCICIALLLVVIPFFTTKTMLALLPIDIYTAIIIANSATVTARAIGVILKY 486

Frog   426 ALFMVELFHDSQVEKIDEIIYYVNAVSRVLEFLVAVCVVAYGTWESLFGEWSWMGVSVIIVHSYF 490
            .:.:||...:...|.||::.||::..::.:|.|.|..|:.:|..:.:...:|:...::::.|...
Worm   487 IVLIVETKSEEPWEGIDDLTYYIDCANKGIELLAAKVVMVFGCMQVVKVGFSFATFAILLFHVIV 551

Frog   491 NVWLRAQSGWKSFLLRREAA-KKISSLPMATLEQLRAHNDVCPICFQDM-SGAVITPCSHIFHGE 553
            |::.|.:. ..||:..|.|| |.|:.|..|.:.|||...|||.|||.:| ..|.||||.|.|||.
Worm   552 NIYKRLEH-TVSFIKNRNAAVKNINRLSKADVVQLREREDVCAICFIEMKEEARITPCKHYFHGP 615

Frog   554 CLRKWLYVQDTCPICHQQVK--------PLAETLREGEEKSE----------EEEEVEADEEVRA 600
            ||||||.|:..||:|:..:|        ..:.||.|.::..|          .||:.||....||
Worm   616 CLRKWLAVKMVCPLCYTYMKEDDFDSKSSSSGTLNEVQQNEEGAAVEENPENPEEQPEAPNAERA 680

Frog   601 E------VTAHGFRRNQCNPERGREEMELGEDRRD------QTNGGERRCDAKHEREEVEEED 651
            .      ....|||..:  ..|.|.|..: ...||      ..:..|...||..|...:|||:
Worm   681 PGDMFDWDDLFGFRAER--ETRNRNEQRI-HGARDMWPLLVDNDAYESDSDAGSEELVIEEEN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf145l	NP_001106467.1	TRC8_N	5..500	CDD:290425	130/526 (25%)
		zf-rbx1	<528..569	CDD:289448	25/41 (61%)
		zf-RING_2	529..569	CDD:290367	25/40 (63%)
rnf-145	NP_491382.2	TRC8_N	49..556	CDD:372682	128/517 (25%)
rnf-145	NP_491382.2	RING-H2_RNF139_like	590..631	CDD:319390	25/40 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I2007
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I2128
OMA	1	1.010	-	-		QHG46488
OrthoDB	1	1.010	-	-		D302551at33208
OrthoFinder	1	1.000	-	-		FOG0006288
OrthoInspector	1	1.000	-	-		otm21068
Panther	1	1.100	-	-	LDO	PTHR22763
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4575
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.080