DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smyhc2 and zip

DIOPT Version :10

Sequence 1:NP_001096096.2 Gene:smyhc2 / 100124599 ZFINID:ZDB-GENE-070822-12 Length:1939 Species:Danio rerio
Sequence 2:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster


Alignment Length:1975 Identity:761/1975 - (38%)
Similarity:1195/1975 - (60%) Gaps:71/1975 - (3%)


- Green bases have known domain annotations that are detailed below.


Zfish    14 PFLRKSDKERLE----AQTRPFDMKKECFVPDPEVEYVKASVTSRDGDKVTVE-TEFGKTVTVKE 73
            |.|:....||.:    |....:..|:..:||.....:|.||:....||:|.|| .|.||.|.:..
  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119

Zfish    74 VDCHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEV 138
            .|....|||||||:||||..|.|:|.:||.|:|:||.:.:||||||||||.|||||.||:|.:::
  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184

Zfish   139 VVAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAA-- 201
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||:|.|||||||||.|||:|||:.|.:||:  
  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249

Zfish   202 --PGGKKDP---------------------------------------SQEKKGTLEDQIIQCNP 225
              .|....|                                       |..::|.||.|::|.||
  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314

Zfish   226 ALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRVTYQLKAERDYHIFYQIL 290
            .|||||||||::|||||||||||||:|..||.:|.|:||||||||||...|.|.||.:|||||:|
  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379

Zfish   291 SQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDVLGFTQEEKNSIYKLTGA 355
            :...||..|..:: ::...|:::|.|...|..:||..|..||.::.:::|.|.|:.|||:::..|
  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443

Zfish   356 IMHYGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQV 420
            ::.:|:|||:|::..:||.......|.|:|:|:||:..|:.:....||:|||.::|||.|..:||
  Fly   444 VLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQV 508

Zfish   421 YYSIGALAKSVYEKMFLWMVVRINQSLD-TKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEK 484
            .:::.|:||:.||:||.|:|.|||:||| ||:....|||:||:||||||:.|:|||||||:||||
  Fly   509 EFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEK 573

Zfish   485 LQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPMGIMSILEEECMFPKASDATFK 549
            |||.|||.||:||||||::|||||:|||||:|||..|:||:||.|||::|:|||.||||:|.||.
  Fly   574 LQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFV 638

Zfish   550 AKLYDNHLGKNPNFQKPRIVKGRPEAHFALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKSTL 614
            .||...| ..:|.|.|...   |..|.||:|||||.|||:.:.||:||.|||||.:|.|.|.|..
  Fly   639 DKLVSAH-SMHPKFMKTDF---RGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQD 699

Zfish   615 KLLGTLF--ANYAG-AESA--DSGGKGKGGAKKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVR 674
            ..:..::  |...| |:.|  |:    :.||:.:...|:|||.|::|.|.|||..||:|:|:|||
  Fly   700 PFVVNIWKDAEIVGMAQQALTDT----QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760

Zfish   675 CLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPSAIPEGQFI 739
            |:|||..|..|.::.|||:.|||||||||||||||:||||||.:.:|:|||.:|.|:.||:| |:
  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FM 824

Zfish   740 DNKKGAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIITGIQARARGILSRIEF 804
            |.||..||::.:|::|.|.|::|.:|:||:||:|..|||.||.:::.:|...||..||.|:|..:
  Fly   825 DGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNY 889

Zfish   805 QKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEEFTKLKEAYAKS 869
            ||.:::.:::.:||.|..|::.::||.|.:||.|:||||:..:.|:::...::|..:::|.....
  Fly   890 QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTL 954

Zfish   870 EARKKELEEKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKIQFEAKVKELTERLEDEEE 934
            ....:|.|.|....|.||..|...:|:|.:..|:|||....|:..|.:.|..::||..|:|:|||
  Fly   955 AKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEE 1019

Zfish   935 MNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALDEIIAKLTKEK 999
            ....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.|||
  Fly  1020 RVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEK 1084

Zfish  1000 KALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1064
            |.|:|........|..||:|...|.|.|||.|..:.:||..|.::::.|.:.:|:|||:|.::..
  Fly  1085 KLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVAD 1149

Zfish  1065 TQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQALEAQLQKKLKELQARIEELEEELEAER 1129
            .:|.|.:......:|:.:|.|::.|::|...:|::|.|.:|..||..:||::::.|::|:||||:
  Fly  1150 LKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEK 1214

Zfish  1130 AARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATAST 1194
            |||||.||.|.|||.|||.:...|.::...||||.|:..|||.|...|::.|||.|:.||...:.
  Fly  1215 AARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLAD 1279

Zfish  1195 LRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCRTLEDQM 1259
            :|.||:..::.:.:|::||::.|..|||.|..|..|..|:.:.:..:..::...::..:..|.|:
  Fly  1280 MRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQI 1344

Zfish  1260 SEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDLKRQLEE 1324
            :|.:.|..|.:|..::...:..|||.|...::.||||.:...|...:...:...|:.:.::.|||
  Fly  1345 AELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEE 1409

Zfish  1325 EVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAIQRTEEL 1389
            |.:.|..|:..::....:.|.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||
  Fly  1410 ETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKEL 1473

Zfish  1390 EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1454
            ||.||:|.:.::..|..|:.:.|:...|:|:|.::|:|:||..:::|........|:|||:||||
  Fly  1474 EEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDK 1538

Zfish  1455 VLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEESLDHLESMKRENKNLQEEISDLTEQL 1519
            :|||.|...|:...|.::|::|:|...|::..:....:|:.|.:|.::.:.|.||.|:.||....
  Fly  1539 ILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQ 1603

Zfish  1520 GESGKNIHELEKVRKQLEQEKQEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDE 1584
            |.:.||:|||||.::.||.:..|::...||.|..|:..|...||.::....:::..||.|..|:|
  Fly  1604 GTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEE 1668

Zfish  1585 EMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGL 1649
            ..|:.:|...:.:..|::.|:.|.:.|..|:..|||:||||.|:|..:...|:...:|.|..|.|
  Fly  1669 GAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKL 1733

Zfish  1650 HGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELMDVSE 1714
            ...:|||....::|....::|:......||:...|:||:.:|...:..:||.|:.||.|..:::|
  Fly  1734 QAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAE 1798

Zfish  1715 RVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQ 1776
            .:....::.:.::::|::||.....|:.|:||   |..|:|   ::::||......:..||..|:
  Fly  1799 EIANNANKGSLMIDEKRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEK 1860

Zfish  1777 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLESRVRELESEVEMEQRKASDSVK 1841
            ..|...|..:..:|:..|:|:.:|.|.|.......|..:..||:::..||.::|.|.::.....|
  Fly  1861 SNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQK 1925

Zfish  1842 GVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRTAEEAEEQANSNLGKFRKLQHEL 1906
            ..||.:::|||||...|::|:::.:.::.:|||..::|..||..:|.||:......:.||.|.|.
  Fly  1926 ANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQREC 1990

Zfish  1907 DEAEERADIAESQVNKLRAKSRDSG 1931
            ::..|..:....::|.|:.|.|.:|
  Fly  1991 EDMIESQEAMNREINSLKTKLRRTG 2015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smyhc2NP_001096096.2 Myosin_N 32..76 CDD:460670 15/44 (34%)
MYSc_class_II 99..769 CDD:276951 357/718 (50%)
Myosin_tail_1 849..1926 CDD:460256 334/1079 (31%)
zipNP_523860.2 Myosin_N 79..122 CDD:460670 15/42 (36%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 357/718 (50%)
Myosin_tail_1 931..2011 CDD:460256 334/1083 (31%)

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