DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smyhc2 and zip

DIOPT Version :9

Sequence 1:	NP_001096096.2	Gene:	smyhc2 / 100124599	ZFINID:	ZDB-GENE-070822-12	Length:	1939	Species:	Danio rerio
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	1975	Identity:	761/1975 - (38%)
Similarity:	1195/1975 - (60%)	Gaps:	71/1975 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish    14 PFLRKSDKERLE----AQTRPFDMKKECFVPDPEVEYVKASVTSRDGDKVTVE-TEFGKTVTVKE 73
            |.|:....||.:    |....:..|:..:||.....:|.||:....||:|.|| .|.||.|.:..
  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119

Zfish    74 VDCHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEV 138
            .|....|||||||:||||..|.|:|.:||.|:|:||.:.:||||||||||.|||||.||:|.:::
  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184

Zfish   139 VVAYRGKKRTEAPPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAA-- 201
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||:|.|||||||||.|||:|||:.|.:||:
  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249

Zfish   202 --PGGKKDP---------------------------------------SQEKKGTLEDQIIQCNP 225
              .|....|                                       |..::|.||.|::|.||
  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314

Zfish   226 ALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRVTYQLKAERDYHIFYQIL 290
            .|||||||||::|||||||||||||:|..||.:|.|:||||||||||...|.|.||.:|||||:|
  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379

Zfish   291 SQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDVLGFTQEEKNSIYKLTGA 355
            :...||..|..:: ::...|:::|.|...|..:||..|..||.::.:::|.|.|:.|||:::..|
  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443

Zfish   356 IMHYGNMKFKQKQREEQAEADGTEDADKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQV 420
            ::.:|:|||:|::..:||.......|.|:|:|:||:..|:.:....||:|||.::|||.|..:||
  Fly   444 VLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQV 508

Zfish   421 YYSIGALAKSVYEKMFLWMVVRINQSLD-TKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEK 484
            .:::.|:||:.||:||.|:|.|||:||| ||:....|||:||:||||||:.|:|||||||:||||
  Fly   509 EFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEK 573

Zfish   485 LQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPMGIMSILEEECMFPKASDATFK 549
            |||.|||.||:||||||::|||||:|||||:|||..|:||:||.|||::|:|||.||||:|.||.
  Fly   574 LQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFV 638

Zfish   550 AKLYDNHLGKNPNFQKPRIVKGRPEAHFALVHYAGTVDYNISNWLVKNKDPLNETVVGLFQKSTL 614
            .||...| ..:|.|.|...   |..|.||:|||||.|||:.:.||:||.|||||.:|.|.|.|..
  Fly   639 DKLVSAH-SMHPKFMKTDF---RGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQD 699

Zfish   615 KLLGTLF--ANYAG-AESA--DSGGKGKGGAKKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVR 674
            ..:..::  |...| |:.|  |:    :.||:.:...|:|||.|::|.|.|||..||:|:|:|||
  Fly   700 PFVVNIWKDAEIVGMAQQALTDT----QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760

Zfish   675 CLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRILNPSAIPEGQFI 739
            |:|||..|..|.::.|||:.|||||||||||||||:||||||.:.:|:|||.:|.|:.||:| |:
  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FM 824

Zfish   740 DNKKGAEKLLGSLDIDHNQYKLGHTKVFFKAGLLGTLEEMRDDRLALIITGIQARARGILSRIEF 804
            |.||..||::.:|::|.|.|::|.:|:||:||:|..|||.||.:::.:|...||..||.|:|..:
  Fly   825 DGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNY 889

Zfish   805 QKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEEFTKLKEAYAKS 869
            ||.:::.:::.:||.|..|::.::||.|.:||.|:||||:..:.|:::...::|..:::|.....
  Fly   890 QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTL 954

Zfish   870 EARKKELEEKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKIQFEAKVKELTERLEDEEE 934
            ....:|.|.|....|.||..|...:|:|.:..|:|||....|:..|.:.|..::||..|:|:|||
  Fly   955 AKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEE 1019

Zfish   935 MNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAALDEIIAKLTKEK 999
            ....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.|||
  Fly  1020 RVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEK 1084

Zfish  1000 KALQEAHQQTLDDLQSEEDKVNTLTKAKAKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1064
            |.|:|........|..||:|...|.|.|||.|..:.:||..|.::::.|.:.:|:|||:|.::..
  Fly  1085 KLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVAD 1149

Zfish  1065 TQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQALEAQLQKKLKELQARIEELEEELEAER 1129
            .:|.|.:......:|:.:|.|::.|::|...:|::|.|.:|..||..:||::::.|::|:||||:
  Fly  1150 LKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEK 1214

Zfish  1130 AARAKVEKQRADLSRELEEISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATAST 1194
            |||||.||.|.|||.|||.:...|.::...||||.|:..|||.|...|::.|||.|:.||...:.
  Fly  1215 AARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLAD 1279

Zfish  1195 LRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCRTLEDQM 1259
            :|.||:..::.:.:|::||::.|..|||.|..|..|..|:.:.:..:..::...::..:..|.|:
  Fly  1280 MRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQI 1344

Zfish  1260 SEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDLKRQLEE 1324
            :|.:.|..|.:|..::...:..|||.|...::.||||.:...|...:...:...|:.:.::.|||
  Fly  1345 AELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEE 1409

Zfish  1325 EVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAIQRTEEL 1389
            |.:.|..|:..::....:.|.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||
  Fly  1410 ETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKEL 1473

Zfish  1390 EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1454
            ||.||:|.:.::..|..|:.:.|:...|:|:|.::|:|:||..:::|........|:|||:||||
  Fly  1474 EEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDK 1538

Zfish  1455 VLAEWKQKYEESQTELESAQKESRSLSTELFKLKNSYEESLDHLESMKRENKNLQEEISDLTEQL 1519
            :|||.|...|:...|.::|::|:|...|::..:....:|:.|.:|.::.:.|.||.|:.||....
  Fly  1539 ILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQ 1603

Zfish  1520 GESGKNIHELEKVRKQLEQEKQEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDE 1584
            |.:.||:|||||.::.||.:..|::...||.|..|:..|...||.::....:::..||.|..|:|
  Fly  1604 GTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEE 1668

Zfish  1585 EMEQAKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGL 1649
            ..|:.:|...:.:..|::.|:.|.:.|..|:..|||:||||.|:|..:...|:...:|.|..|.|
  Fly  1669 GAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKL 1733

Zfish  1650 HGHLKDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELMDVSE 1714
            ...:|||....::|....::|:......||:...|:||:.:|...:..:||.|:.||.|..:::|
  Fly  1734 QAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAE 1798

Zfish  1715 RVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQ 1776
            .:....::.:.::::|::||.....|:.|:||   |..|:|   ::::||......:..||..|:
  Fly  1799 EIANNANKGSLMIDEKRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEK 1860

Zfish  1777 DTSAHLERMKKNMEQTIKDLQHRLDEAEQIAMKGGKKQVQKLESRVRELESEVEMEQRKASDSVK 1841
            ..|...|..:..:|:..|:|:.:|.|.|.......|..:..||:::..||.::|.|.::.....|
  Fly  1861 SNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQK 1925

Zfish  1842 GVRKYERRIKELTYQTEEDRKNLARLQDLVDKLQLKVKSYKRTAEEAEEQANSNLGKFRKLQHEL 1906
            ..||.:::|||||...|::|:::.:.::.:|||..::|..||..:|.||:......:.||.|.|.
  Fly  1926 ANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQREC 1990

Zfish  1907 DEAEERADIAESQVNKLRAKSRDSG 1931
            ::..|..:....::|.|:.|.|.:|
  Fly  1991 EDMIESQEAMNREINSLKTKLRRTG 2015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smyhc2	NP_001096096.2	Myosin_N	35..72	CDD:280832	14/37 (38%)
		Myosin_head	87..769	CDD:278492	364/730 (50%)
		MYSc_class_II	99..769	CDD:276951	357/718 (50%)
		Myosin_tail_1	849..1926	CDD:279860	334/1079 (31%)
		RILP-like	964..1097	CDD:304877	42/132 (32%)
		mycoplas_twoTM	1184..>1321	CDD:275320	33/136 (24%)
		MIT_CorA-like	<1298..>1410	CDD:294313	32/111 (29%)
		COG6	1375..>1508	CDD:303003	44/132 (33%)
		TMPIT	1458..>1563	CDD:285135	33/104 (32%)
		TMPIT	1743..>1828	CDD:285135	24/87 (28%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	14/36 (39%)
		Myosin_head	133..854	CDD:278492	364/730 (50%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	357/718 (50%)
		Myosin_tail_1	931..2011	CDD:279860	334/1083 (31%)
		Prefoldin	1431..1515	CDD:298833	30/84 (36%)
		FAM76	<1847..1926	CDD:292665	18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820