Protein Alignment ZBTB33 and CG10321

DIOPT Version :10

• Sequence 1: NP_006768.1
• Gene: ZBTB33 / 10009
• HGNCID: 16682
• Length: 672
• Species: Homo sapiens
• Sequence 2: NP_001261124.1
• Gene: CG10321 / 37464
• FlyBaseID: FBgn0034643
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 117/587 - (19%)
• Similarity: 197/587 - (33%)
• Gaps: 200/587 - (34%)

Human   202 LPTKETLPSNN--TVAQVQSNPGPVAISDVAPSASNN---SPPLTNITPTQKLPTPVNQA--TLS 259
            :|.:..||:..  |.||:.: |....|...||.::.|   :...:...| |.|.||..|.  .:.
  Fly   221 MPQQILLPNGQLITTAQIVA-PQLAQIISTAPQSTTNGQATAAQSQFLP-QLLQTPNGQTLQIVQ 283

Human   260 QTQGSEKLLV-------SSAPTHLTPNIILLNQTPLSTPPNVSSSLPNHMPSSINLL-----VQN 312
            |..|::.|.:       |.|||.:|......|.|.:.  .:|.:||.:   :.:.||     |::
  Fly   284 QPNGTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMG--QHVGASLGD---ADVQLLEDGCEVED 343

Human   313 QQTPNSAILTGNKANEEEEEEIIDDD-------------------DDTISSSPDSAV-------- 350
            ::..:......:||:...|..::|||                   |.|.|.|.|...
  Fly   344 EELEDVYEQLDSKADHSFETIVLDDDQQQDFLKDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQ 408

Human   351 -------SNTSLVPQADTSQNTSFDGSLIQKMQI--PTLLQEPLSNSLKISDIITRNTNDPGVGS 406
                   ....:.|:.|.      |..:|:::|:  ..:|.:|....:...........||.:..
  Fly   409 AMDEIEDEEEQMKPEEDQ------DTFIIEEIQLEDDEMLDDPDGEEIDQDCEYIGEEQDPHLSG 467

Human   407 K-------HLME---GQKIITLDTA-------------TEIEGLSTGCKV--YANIGEDTYDIVI 446
            .       .:||   |:..:.:|.|             .|::.:|....|  ::.....|..:|.
  Fly   468 DVDDDLEYSIMEPPDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVG 532

Human   447 PV----KDDPDEGEARLEN-EIP----------------KTSGSEM--ANKRMKVK--------- 479
            |.    ...|....|:..| :||                .|:.|::  ||.|..|:
  Fly   533 PTMTVSSASPTPKRAKRSNHQIPAGVTLEPCDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAG 597

Human   480 HDDHYEL---------------IVDGRVYYICIVCKRSY-------------------------- 503
            .||:||:               :..||  |||.:|...:
  Fly   598 ADDNYEIDANLVTEFIRQHTSPLGSGR--YICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQ 660

Human   504 --VCLTS------LRRHFNIHSWEKKYP-CRYCEKVFP----LAEYRTKHEIHHTGERRYQC--L 553
              :||.|      ||.|...|..|...| |..|.:.|.    |..:|..|:     :|.|.|  .
  Fly   661 CQICLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQ-----QRAYCCGVA 720

Human   554 ACGKSFINYQFMSSHIKSVHSQ--DPSGDSKLYRLHPCRSL-----QIRQYAYLSDRSSTIPAMK 611
            .|.|:|.:...:..|::..|.:  ||     |::...|.||     .::.:...:|.|:.:....
  Fly   721 NCRKNFSSAVNLKWHVERKHPEVVDP-----LFKCGECGSLYDNVDSLQLHVESTDHSAEVQISG 780

Human   612 DD 613
            .|
  Fly   781 QD 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB33	NP_006768.1	Self-association. /evidence=ECO:0000250	1..136
		Interaction with NCOR1. /evidence=ECO:0000269|PubMed:14527417	1..103
		BTB_POZ_ZBTB33_KAISO	11..116	CDD:349528
		PRK11901	209..>322	CDD:237015	31/131 (24%)
		Interaction with CBFA2T3. /evidence=ECO:0000269|PubMed:23251453	298..573		78/428 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..354		11/62 (18%)
		Interaction with CTNND1. /evidence=ECO:0000250	454..672		52/251 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	471..480		4/19 (21%)
		C2H2 Zn finger	496..516	CDD:275368	8/53 (15%)
		zf-H2C2_2	508..531	CDD:463886	9/29 (31%)
		Required for DNA-binding. /evidence=ECO:0000250	514..638		26/114 (23%)
		C2H2 Zn finger	524..544	CDD:275368	6/23 (26%)
		zf-H2C2_2	539..561	CDD:463886	7/23 (30%)
		C2H2 Zn finger	552..573	CDD:275368	5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..635
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		COG5137	<405..516	CDD:227466	16/116 (14%)
		C2H2 Zn finger	627..647	CDD:275368	2/19 (11%)
		zf-C2H2	660..681	CDD:395048	6/20 (30%)
		C2H2 Zn finger	661..681	CDD:275368	6/19 (32%)
		SUF4-like	688..>745	CDD:411020	15/61 (25%)
		C2H2 Zn finger	690..714	CDD:411020	6/28 (21%)
		C2H2 Zn finger	690..710	CDD:275368	5/19 (26%)
		C2H2 Zn finger	717..740	CDD:411020	5/22 (23%)
		C2H2 Zn finger	717..740	CDD:275368	5/22 (23%)
		C2H2 Zn finger	750..767	CDD:275368	3/16 (19%)