DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC14 and wrk-1

DIOPT Version :9

Sequence 1:	NP_001092082.1	Gene:	SIGLEC14 / 100049587	HGNCID:	32926	Length:	396	Species:	Homo sapiens
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	375	Identity:	72/375 - (19%)
Similarity:	124/375 - (33%)	Gaps:	115/375 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     2 LPLLLLPLL----------WGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPL 56
            |.||:|.||          .||:|..|              ||..:.:.|.        ...|.:
Worm     4 LVLLILGLLIASTSAQIRTKGGTLIAK--------------EGESLTLRCE--------VEDPSV 46

Human    57 YVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFF--R 119
            .:.|.::      .||||.::...    :|.|.:.:                .||.:.|...  |
Worm    47 AIIWRKN------TEVVAVDDEIL----DTYGGYEI----------------SMEGSTSVLTIKR 85

Human   120 VERGRDVKYSYQQNKLNLEVTALIE----KPDIHFLEPLESGRPTR-------------LSCSLP 167
            ||......||....:..:.||.:|:    ||....::||....|..             ::|.:.
Worm    86 VEPINSANYSCALAEPEVSVTFVIKVQVFKPTQVSVKPLVVISPDTGVYHARVGEKNLVITCHVK 150

Human   168 GSCEAGPPLTFSWTGNALSPLDPETTR---SSELTLTPRPEDHGTNLTCQVKRQGAQVTTERTVQ 229
               |..|.....||..| :.|..:..|   .:.:.:|...:.|.....|..:....  :...|:.
Worm   151 ---EGNPKPGVVWTKQA-AKLPEDIKREHGGARIVITEVKKHHAGKYNCLAENIAG--SDRATID 209

Human   230 LNVSYAPQNLAISIFFRNGTGTALR---ILSNGMSVPIQEGQSLFLACTVDSNPPASLSWFREGK 291
            ::|:...|            |....   :.:....:|:::.|:....||.|..|...:.|...|.
Worm   210 IHVAEPLQ------------GEREEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFNGY 262

Human   292 ALN--------PSQTSM------SGTLELPNIGAREGGEFTCRVQHPLGS 327
            .:|        .|:|:.      ..||.:.:|.....|::.||:.:.|||
Worm   263 KINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLGS 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC14	NP_001092082.1	Ig_Siglec_N	21..140	CDD:143189	19/120 (16%)
		IG_like	26..139	CDD:214653	19/114 (17%)
		Ig	150..216	CDD:299845	14/81 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..209		3/21 (14%)
		Ig	252..335	CDD:299845	20/93 (22%)
		IG_like	261..336	CDD:214653	20/81 (25%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	25/135 (19%)
		IGc2	31..96	CDD:197706	18/98 (18%)
		IG_like	132..212	CDD:214653	12/85 (14%)
		IGc2	142..202	CDD:197706	11/63 (17%)
		IG_like	235..320	CDD:214653	19/78 (24%)
		Ig	245..318	CDD:143165	18/68 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000