DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC14 and si:ch73-380l3.2

DIOPT Version :9

Sequence 1:	NP_001092082.1	Gene:	SIGLEC14 / 100049587	HGNCID:	32926	Length:	396	Species:	Homo sapiens
Sequence 2:	NP_001348166.1	Gene:	si:ch73-380l3.2 / 100003913	ZFINID:	ZDB-GENE-080303-1	Length:	266	Species:	Danio rerio

Alignment Length:	215	Identity:	62/215 - (28%)
Similarity:	96/215 - (44%)	Gaps:	26/215 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    20 VYELQVQKSVTVQEGLCVLVPCSFSYPWRSWYSSPPLY---VYWFRDG---EIPYYAEVVATNNP 78
            |:::.|:..:......||::||:|:||...  ...|.|   ..|.:..   :|.:|.:...
Zfish    23 VWKVDVEHKMKALVSSCVVLPCNFTYPVHQ--QQQPSYRIRGIWHKMNKWDDIIFYGDKTL---- 81

Human    79 DRRVKPETQGRFRLLGDVQKKNCSLSIGDARMEDTGSYFFRVE---RGRDVKYSYQQNKLNLEVT 140
               |:...:||.||:|.:...||||.|.:.:..|.|.|.||||   ..:| |||:..|.:::...
Zfish    82 ---VEDNFKGRTRLIGSLGSFNCSLEIDEVKNTDNGPYCFRVELETAPKD-KYSFVDNCVSITTI 142

Human   141 ALIEKPDIHFLEPLESGRPTRLSCSLPGSCEAGPPLTFSW--TGNALSPLDP----ETTRSSELT 199
            ....||.:.....:..|.|....||:..:|....| :|||  .|..:|..:.    .....|.||
Zfish   143 EEAPKPMLEAETSVLEGEPAIFKCSVRHTCPTYQP-SFSWNRAGKIISSYNDLGHGNWEAESLLT 206

Human   200 LTPRPEDHGTNLTCQVKRQG 219
            .||..||:.|::.|.||..|
Zfish   207 FTPTKEDNYTSIECTVKYHG 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC14	NP_001092082.1	Ig_Siglec_N	21..140	CDD:143189	36/127 (28%)
		IG_like	26..139	CDD:214653	35/121 (29%)
		Ig	150..216	CDD:299845	20/71 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..209		7/22 (32%)
		Ig	252..335	CDD:299845
		IG_like	261..336	CDD:214653
si:ch73-380l3.2	NP_001348166.1	Ig	24..141	CDD:325142	36/126 (29%)
si:ch73-380l3.2	NP_001348166.1	Ig	148..226	CDD:325142	23/78 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I12412
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.060