DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUXB and hbn

DIOPT Version :9

Sequence 1:	NP_001338236.1	Gene:	DUXB / 100033411	HGNCID:	33345	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_788420.1	Gene:	hbn / 47894	FlyBaseID:	FBgn0008636	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	181	Identity:	51/181 - (28%)
Similarity:	82/181 - (45%)	Gaps:	46/181 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    86 GHDQSQHLTQEYLPKEARQKQTFITWTQKNRLVQAFERNPFPDIATRKKLAEQTGLQESRIQMWF 150
            |||    |:....|::.|:.:|..|..|.::|.:|||:..:||:.||:.||.:..|.|:|:|:||
  Fly   141 GHD----LSDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWF 201

Human   151 QKQRSLYLKKSRMEPMN------LLVDDPNERPDATVGWHPINLFLPTDSSHYFSCSHSSSGHET 209
            |.:|:.:.|:.:.  ||      ||       |:..:...|:.:.||         .|...||.
  Fly   202 QNRRAKWRKREKF--MNQDKAGYLL-------PEQGLPEFPLGIPLP---------PHGLPGHP- 247

Human   210 LPPVLPSTQAPWDPFRFHVSQGPNVMIMQPTQAVQEGEKSDQPLIIPNHLL 260
                 .|.|:.:.|..|.:.|..|     |..|...|       ::|.||:
  Fly   248 -----GSMQSEFWPPHFALHQHFN-----PAAAAAAG-------LLPQHLM 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUXB	NP_001338236.1	homeodomain	16..72	CDD:238039
		homeodomain	103..161	CDD:238039	23/57 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314
hbn	NP_788420.1	Homeobox	156..209	CDD:278475	21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910