DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUXB and gsb-n

DIOPT Version :9

Sequence 1:	NP_001338236.1	Gene:	DUXB / 100033411	HGNCID:	33345	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	245	Identity:	61/245 - (24%)
Similarity:	100/245 - (40%)	Gaps:	56/245 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     5 GTSGG----ILQKEFWRNRIQYNQSQKDILQSWFQHDPFPDKAAREQLAKE-IGVPESNIQVWFK 64
            |..||    :...|. ..||...:.:...:.||         ..||:|.|| ...|.|...: .:
  Fly    85 GVIGGSKPKVTSPEI-ETRIDELRKENPSIFSW---------EIREKLIKEGFADPPSTSSI-SR 138

Human    65 NYRVKQRKLDYKCFSEKDQT-------QGHDQSQHLTQEYLPKEARQKQTFITWT--QKNRLVQA 120
            ..|...|..:   ...||.|       :..|.|...::..:|.:.:|:::..|:|  |...|.:|
  Fly   139 LLRGSDRGSE---DGRKDYTINGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERA 200

Human   121 FERNPFPDIATRKKLAEQTGLQESRIQMWFQKQRSLYLK-----KSRMEPM-----NLLVDDPNE 175
            |.|..:||:.||::||:.|.|.|:|||:||..:|:...|     .|.:.||     |:.|.....
  Fly   201 FSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSNSGLSPMNSGSSNVGVGVGLS 265

Human   176 RPDATVGWHPINL-----FLP-----------TDSSHYFSCSHSSSGHET 209
            ...|.:|:.|:.:     :.|           .|..|:  .:|:.|.|.:
  Fly   266 GATAPLGYGPLGVGSMAGYSPAPGTTATGAGMNDGVHH--AAHAPSSHHS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUXB	NP_001338236.1	homeodomain	16..72	CDD:238039	12/56 (21%)
		homeodomain	103..161	CDD:238039	24/64 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..314
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	15/66 (23%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	22/52 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910