DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klf5a and mamo

DIOPT Version :9

Sequence 1:	XP_001344916.5	Gene:	klf5a / 100006043	ZFINID:	ZDB-GENE-090312-167	Length:	429	Species:	Danio rerio
Sequence 2:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	91/394 - (23%)
Similarity:	129/394 - (32%)	Gaps:	147/394 - (37%)

- Green bases have known domain annotations that are detailed below.

Zfish   146 SSSGPAPSAL------PDFTSIFNSNSTSGSGMDVVDDSAGVFVKQEMQGF--DIPQDGP----- 197
            |.|||:.||:      |  ||:..|.|.:....|||..|....:..|.:..  ::.::|.
  Fly  1189 SGSGPSSSAISVSVAAP--TSVSASGSVTSVDQDVVTSSQEPMLADEGEDLRVNVKREGTADEQS 1251

Zfish   198 ------------------------LFQLLNSELDV----------------------------PD 210
                                    |:|..||....                            .|
  Fly  1252 AESRANDLEEHEQDNTVDSAGITMLYQDNNSSASASTSATEPNISSSDGIHSTNKRSRLHHLETD 1316

Zfish   211 PTDPHAHSQMPTFHNLHLAAQQTAAKSYCGMAAHGYPLSHGHFVHPQDQAHSQLKMTYLPPSPPT 275
            |:.||.|..    |:.|...||           | :...|.|. :||.|..:.|....| |...|
  Fly  1317 PSYPHHHHH----HHHHHHQQQ-----------H-HQAQHQHH-NPQSQLPTHLGHVSL-PLVAT 1363

Zfish   276 SEPGSPDRQKELLHNLTPPPSYAATIASKMA----GHAPSHPTPASARPPTTTGS---------- 326
            |..||           :...:.||.:|:..|    |...|..|.:.|......||
  Fly  1364 SAAGS-----------SSSAAAAAVVAAAQAQVSSGATGSGATGSGAPGSGNVGSAGSSGAGGGI 1417

Zfish   327 --------------MPVRYNRRTNPD------------LEKRRIHH-------CDFPGCKKVYTK 358
                          :|.......||.            .|::|...       |.|  |.|....
  Fly  1418 SSLSSLTSLINAERIPNEQFLGLNPQEASILNFLRVDAAERQRDKRPATSRFACPF--CGKCVRS 1480

Zfish   359 SSHLKAHLRTHTGEKPYRCTWEGCDWRFARSDELTRHFRKHTGAKPFQCAVCSRSFSRSDHLALH 423
            ..:||.|:|.||||:|:.|.:  |...|....:||||.|.|||.:|:.|..|.:.|:|:|:|:.|
  Fly  1481 KENLKLHVRKHTGERPFVCLF--CGRAFGGKSDLTRHLRIHTGERPYHCESCGKCFARADYLSKH 1543

Zfish   424 MKRH 427
            :..|
  Fly  1544 LTTH 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klf5a	XP_001344916.5	COG5048	322..>408	CDD:227381	32/128 (25%)
		C2H2 Zn finger	350..369	CDD:275368	6/18 (33%)
		zf-H2C2_2	361..>378	CDD:290200	9/16 (56%)
		C2H2 Zn finger	377..399	CDD:275368	8/21 (38%)
		zf-H2C2_2	391..416	CDD:290200	12/24 (50%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
mamo	NP_572932.2	BTB	21..118	CDD:279045
		BTB	32..118	CDD:197585
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523	8/23 (35%)
		C2H2 Zn finger	1471..1491	CDD:275368	8/21 (38%)
		zf-H2C2_2	1483..1506	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1499..1519	CDD:275368	8/21 (38%)
		zf-H2C2_2	1511..1536	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1527..1547	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910