DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spop and rdx

DIOPT Version :9

Sequence 1:	NP_957424.1	Gene:	spop / 100005514	ZFINID:	ZDB-GENE-040426-1378	Length:	374	Species:	Danio rerio
Sequence 2:	NP_650326.3	Gene:	rdx / 41704	FlyBaseID:	FBgn0264493	Length:	829	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	296/374 - (79%)
Similarity:	336/374 - (89%)	Gaps:	2/374 - (0%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MSRVPSPPPPAEMTSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65
            :|||||||.|...|  ||||:|||||:||||||||||||||||||||||||:||||||:||||||
  Fly   458 VSRVPSPPLPEVNT--PVAENWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSAGANDKL 520

Zfish    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130
            ||||||||||||||||||||||||||||.||||||||||||||||.|||||||||||||||||||
  Fly   521 KWCLRVNPKGLDEESKDYLSLYLLLVSCNKSEVRAKFKFSILNAKREETKAMESQRAYRFVQGKD 585

Zfish   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPDCRLADELGGLWE 195
            |||||||||||||||||||||:||||:|||||||.||||||||:.:...|||:|:|:::||.|::
  Fly   586 WGFKKFIRRDFLLDEANGLLPEDKLTIFCEVSVVADSVNISGQSNIVQFKVPECKLSEDLGNLFD 650

Zfish   196 HSRFTDCSLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEAEVFKEMMFFIYT 260
            :.:|:|.:|.|.|:|||||||||||||.||:|||||||||.|.|||.|.||:.||.|||:.||||
  Fly   651 NEKFSDVTLSVGGREFQAHKAILAARSDVFAAMFEHEMEERKLNRVAITDVDHEVLKEMLRFIYT 715

Zfish   261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCTSLSVENAAEILILADLHSADQLKTQAVDFI 325
            ||||||:||||||||||||||||:||||||:|||.:||||.|||.|||||||||||||.|.:|||
  Fly   716 GKAPNLEKMADDLLAAADKYALEKLKVMCEEALCVNLSVETAAETLILADLHSADQLKAQTIDFI 780

Zfish   326 NYHASDVMETSGWKSMVASHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374
            |.||:||||||||::|:.:|.||:|||:|:||:.|.|.:||||||:|.|
  Fly   781 NTHATDVMETSGWQNMITTHSHLIAEAFRALATQQIPPIGPPRKRVKMS 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spop	NP_957424.1	MATH_SPOP	28..166	CDD:239743	131/137 (96%)
		Required for nuclear localization. /evidence=ECO:0000250	71..191		103/119 (87%)
		BTB_POZ	179..301	CDD:365784	87/121 (72%)
		BACK_SPOP	297..367	CDD:350593	48/69 (70%)
		Homodimerization. /evidence=ECO:0000250	297..355		42/57 (74%)
rdx	NP_650326.3	MATH_SPOP	483..621	CDD:239743	131/137 (96%)
		BTB	645..749	CDD:279045	77/103 (75%)
		BTB	656..752	CDD:197585	75/95 (79%)
		SPOP_C	752..814	CDD:269807	45/61 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68354
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D864323at2759
OrthoFinder	1	1.000	-	-		FOG0000398
OrthoInspector	1	1.000	-	-		otm25147
orthoMCL	1	0.900	-	-		OOG6_101509
Panther	1	1.100	-	-	O	PTHR24413
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2421
SonicParanoid	1	1.000	-	-		X131
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.950