Protein Alignment stard13b and cv-c

DIOPT Version :9

• Sequence 1: XP_005157695.1
• Gene: stard13b / 100005208
• ZFINID: ZDB-GENE-050506-146
• Length: 1487
• Species: Danio rerio
• Sequence 2: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 1651
• Identity: 496/1651 - (30%)
• Similarity: 756/1651 - (45%)
• Gaps: 364/1651 - (22%)

Zfish     5 PMMALEERRSSALKMTFSGELSMADSTKACNQTSKNTPNSLSITDDPLEDQTKLELKNKSSLERE 69
            |.:..:.:|.|......:|:......|.|.::.: |..::|.|     |:....:....::.|.:
  Fly   897 PALPPQSQRKSLACPPLNGQADTITPTPATHKLT-NFQSALKI-----EEMAAAKGTAMATGESQ 955

Zfish    70 ISQTVSSQISKDGPCIQISNHLTKEKTKTCIKSASDSISSPNPKLNGINHESHMKSHFLTP---S 131
            ::.|:....|:.      ...|:....:|.:.|...|:    ||..||||......:.:||   |
  Fly   956 LATTIEDLKSRR------QRQLSGGDMETMLASQPMSM----PKRVGINHAVLTSRNAITPPPAS 1010

Zfish   132 GSPLTNNA--------------------DVDPSNVSLTSYPFSSSKIRSI-----SNPAYSFTS- 170
            .|..:.:|                    ||.....:.|.:....|.:||:     .|.:.|.:|
  Fly  1011 ASSASQSAASVHSAKGSSSAGTTPGYLVDVTKKGSTSTIWTSEESILRSVGAVDEDNNSTSSSSA 1075

Zfish   171 ----------------------------SPVG-------------SSHLKHPY---------SAP 185
                                        |.:|             |.||:|.:         ||.
  Fly  1076 CEEATGVLSSGKSGISLDSSGLDNDNNESGIGTATPPKDMSHYWKSHHLQHHHHHHHRKCTGSAQ 1140

Zfish   186 --LPVSKGSDLPRIIKHKPSSITFADYNDFLGLIQNSRATESSDAFETSSE--DEGQDVV--FHD 244
              ..||....|.::...|..|:..:|..|.|.::  |:.....:|.|:..:  ||.:|.:  ..|
  Fly  1141 DNESVSSLEALRKMKFQKSGSVASSDDPDVLEVL--SQCGSGGEANESQDDMLDEEKDKMSKSQD 1203

Zfish   245 GNEVLP-KCKELQACSRRNRAGLEK----LRRKGTCGQGVGEERSGSKPPL----TSRSSYEAEE 300
            .:|:.. .|.:..|.|.....|:..    ||||.|           :.||:    |.||......
  Fly  1204 YDEIWDCDCTDGDASSASGGGGVTATPVILRRKYT-----------APPPILVPRTQRSHSLDHY 1257

Zfish   301 ESSSTEESPQVVSPWSKSMIQLMKRLDQLNLDI-EEALSAGSSPSDT-------------PSSAR 351
            .|......|:.|.|.....::..:| .||:|.: :|...:..|||.|             ||||.
  Fly  1258 HSPQPLVHPRKVLPIHHHALKSKER-GQLSLVLRQEPFQSLLSPSATAANQLHHFVELPSPSSAS 1321

Zfish   352 RYTA-NDRTALQSGAVEGNQS---INWINMARRSDTRERQSQERHAGATSSMGRSHARKTEMSIK 412
            .::. .|...:|....:.|.:   :....|:||.|..|.|.      .|....||.:.:..
  Fly  1322 LHSGLGDSGGIQELCTKSNSAPMLLKEREMSRRFDNFEAQH------LTLRYSRSQSDRYL---- 1376

Zfish   413 KRHGGAEIEAKEACDWLRAAGFPQYAQLFEDSQFPIDISPVKKDHDFLDKDLVEPLCRRLNTLNK 477
                 |||||.|||.||||||||||||::||.|||||::.|.|||..|:.|.::.|.|||..||:
  Fly  1377 -----AEIEAVEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNR 1436

Zfish   478 CASMKLDVN----LPKKKSEDSDEDDLFAISDKWTFEWSSRRWSRLQDIDCLLRGVENRKPAENS 538
            ||:|:||.:    .|::|.|..||:  ||:|:.|||:...|||||:.::     |:|
  Fly  1437 CATMRLDQSHKPQTPQQKEESDDEN--FALSEHWTFQPHIRRWSRIGEM-----GLE-------- 1486

Zfish   539 ALRTTTSSESVLTDLSEPEISSLHSESSGGSGGVRAHSAEDSDSSHRT-----CSDSAAMP-DHT 597
                          |..|.:.||:.|.:..|....:....:.|.:..|     ||.:..:| |.:
  Fly  1487 --------------LPPPGLLSLNVEKTESSSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGS 1537

Zfish   598 SLGMAHLSSDLSSYGSLPVKHGKRGRTRAKEFLRRMEALQLRGAMSSGGNR-SLVISAPV---LQ 658
            |||....|..|...||      :|.:.:||..|||:|:::.|.....  || ::|||.|.   |.
  Fly  1538 SLGEGSDSGRLRRSGS------ERIKDQAKALLRRVESIKSRRRKRQ--NRENVVISGPTVLDLS 1594

Zfish   659 QEPQTVKTLRCVEIINGDVHLAEPPSGMLLSQSSSEGSSSQSSGSAVSTPNLKER--NVHRADHK 721
            |..|. .:||     ..|...:.|||...||...: ...:...|:.:..|:..:.  :.:|:..|
  Fly  1595 QFGQR-SSLR-----KPDAVYSTPPSPSALSPMHT-FPKAPFFGNDLKVPSHSDNFLSPNRSSPK 1652

Zfish   722 RS-----GMYLEDLDVFSS----LIQGKRVAEQNRRNEFRSYEDLVVHIPKDHKPGTFPKALSIE 777
            |:     .|....|..|||    |.:||
  Fly  1653 RTPTTPRSMRTSPLHFFSSPMSQLKEGK------------------------------------- 1680

Zfish   778 SLSPSTATSINWHSASMDSDVQRPPSIKEPRPVTQCCTRGSRISIYDNVPGSHLYASTGDLIDLE 842
                 :..|.:::|.|.:|......|:::|....:...|..::
  Fly  1681 -----SDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTGKV---------------------- 1718

Zfish   843 KEDLFPHLDDILQHVNGLQQIVDHWSKNVLP---------NSENAGKGQVDLDVEGQDDLQSSSQ 898
             :|:..|.|.  :...|.:.::...:.|...         .|.|.||     |.:.:|..:|||
  Fly  1719 -DDIGAHSDS--ECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGK-----DPKKRDGFRSSS- 1774

Zfish   899 ITLDFEGHSVLEGQATPSDVERDGVSLNETESTGMRERRDSGVGASLTRPKRLRWPSFQISNR-- 961
                |...|....:| .:|.:..|.:.|               |.|..:|. :||.|||:..|
  Fly  1775 ----FRSRSTSRKEA-KNDEDTAGATTN---------------GGSKRQPV-VRWHSFQMEERPN 1818

Zfish   962 -------------LSHSVASLQITSQSAAQLSLLQKFSLLRLTAIMEKYSMSNKHGWTWSVPKFM 1013
                         |......:...:.||.||.:::|.:|:.||..||:|..|::.||.|.:|||:
  Fly  1819 MIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFI 1883

Zfish  1014 KRMKVPDYKDKNVFGVPLIVHVQRFGQPLPLGMQQALRYLRSQCLDQVGLFRKSGVKSRIQALRQ 1078
            |::|:||||||.||||||::.:||.||.|||.::.|.|:|:...|||||:|||||.||||..||:
  Fly  1884 KKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLRE 1948

Zfish  1079 MNESSPDDVNYED----QSAYDVADMVKQFFRDLPEPLLTSKLGETFLHIYQYVPKEQRLQAVQA 1139
            ..|.:.......|    |.|||||||:||:||:|||.|||:|:.|||:.|:|::|.|.||.|||.
  Fly  1949 QIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQC 2013

Zfish  1140 AIMLMSDENREVLQTLLCFLSDVTSSVQENQMTPMNLAVCLAPSLFHLNILKKDNLTPRAMHMQK 1204
            |::|:.|||||:|..||.||:.|.::.|:||||..||.||||.|:||.:| ...:.:..|...:|
  Fly  2014 AVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSI-STGSASVSASPRRK 2077

Zfish  1205 KYATGRPDQKDLNENLAATQGLAHMITECNRLFEIPHEMVTQSRNSYVEAELQAPTIEELCKRQH 1269
            ...:|.||.|:|.|..|:.:.|:.||....:::....|.:::...||:|.....| :|.|
  Fly  2078 GKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAAKEKLSKCNFSYMEESKPLP-LEAL----- 2136

Zfish  1270 PEDDGEDEGSWPAFMEARLQGLLKDSREKAKGWVSCQSTGNT--ELSYKKVGDGNPLRRWRVSVE 1332
              .:|....:|..::.......:|:.|||.:||.|..|..::  :::|||||||:|||.||.|.|
  Fly  2137 --GEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTE 2199

Zfish  1333 VEAPPSVVLNRVLRERHMWDVDLMNWKVSEVLDRQTEVFQYVLNCMPPHPSRDFVVLRSWRTDLP 1397
            :|.||..||..|:::|..||.:|:..:..:.||.:||::||.|:   ...:.||.|||||:||||
  Fly  2200 IEGPPKEVLEFVIKQRASWDTNLLQCQTVKKLDDRTEIYQYALD---GQLTTDFCVLRSWQTDLP 2261

Zfish  1398 RGTCSLVSVSIEHEDCPPV-GGIRAIVMESNYLLEPCGSGKSRLTHICRVDLKGRTPEWYNKAFG 1461
            ||.|.:|..||:|....|: |.:|.:|:.|.||:||||||:||:.|:.|||:||:|||||||.:|
  Fly  2262 RGACVIVETSIDHAKAKPLFGAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNYG 2326

Zfish  1462 HLCAAEAARIRNSFQPIHTEGPETKI 1487
            |:|:...:|||.:|:.: .:|||:|:
  Fly  2327 HICSHYLSRIRLAFKHV-ADGPESKV 2351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stard13b	XP_005157695.1	SAM_DLC2	419..482	CDD:188991	40/62 (65%)
		SAM	423..482	CDD:197735	36/58 (62%)
		RhoGAP_DLC1	1023..1243	CDD:239840	107/223 (48%)
		SRPBCC	1275..1478	CDD:301327	93/205 (45%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	36/58 (62%)
		RhoGAP_DLC1	1893..2116	CDD:239840	107/223 (48%)
		SRPBCC	2148..2343	CDD:301327	92/197 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3074
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I926
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm25015
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	O	PTHR12659
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.990