DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mast2 and dop

DIOPT Version :9

Sequence 1:	XP_009300769.1	Gene:	mast2 / 100001267	ZFINID:	ZDB-GENE-050309-150	Length:	1934	Species:	Danio rerio
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	2226	Identity:	776/2226 - (34%)
Similarity:	1018/2226 - (45%)	Gaps:	672/2226 - (30%)

- Green bases have known domain annotations that are detailed below.

Zfish    34 PLLFRKLSNPDLSPAAGKTKLQ-RQLSQDDSRGRRSSMAGIL--------------TGKQLLP-- 81
            |:..|.||..:||....::... |.|..|||....::.|..|              :|.:|||
  Fly    94 PVPKRHLSTANLSRIRPQSSYSARVLIFDDSDQEAAAAAAALAAASSSCNSSVKSCSGLELLPTS 158

Zfish    82 ---------------------LSSSMHGGVS----------------QLAWQQHT-------GEP 102
                                 |:.|..||:|                ::::||||       ||.
  Fly   159 PAKLSIGNDSTNGSSMMRNLNLTKSSSGGLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGET 223

Zfish   103 NNLVRMRSQSFGQSAPSLTAGL--KELSLP-------------------RRGSFCR--------- 137
            :||:|||..|.|:|||.||...  .||:.|                   |.|| |.
  Fly   224 SNLLRMRHSSLGKSAPCLTGNYFRHELTAPLPVQPPGFGASPLGGHNISRSGS-CAGIGLAKHHH 287

Zfish   138 ---------------------------TSNRKSLIVTSSTSPTL--PRPHSPLHGHPGSSPLDSP 173
                                       ..:|.||:..|:.....  .|.|||.    .:||:|||
  Fly   288 HHHLHGVVMRGSAGGGAGSGGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPY----SASPVDSP 348

Zfish   174 RNFSPNTAAHFSFVP-ARSHGHRADRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQL- 236
            |..||   ..|:|.| .|....|....||||||:||||||||||...||.:||.|||||.|:||
  Fly   349 RLNSP---MPFAFAPIKRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLA 410

Zfish   237 -----------------------------------------------PFQPT------------- 241
                                                           |.:||
  Fly   411 HNIPPGVQEADAAAVAAGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACV 475

Zfish   242 --ADELHFL---------------TKHFSSESITDEDGRRSPAMRPRSRSL-SPGRSPISFDHEI 288
              ..||...               :.:.|..|.....||.||..||||||| ||.|||| .|:||
  Fly   476 NCCAELSVTCGGQQAGGGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSPI-VDNEI 539

Zfish   289 VMMNHVYKERFPKATAQMEVRLADFISSSAPEKVMPLADG--VLSFIHHQVIELSRDCLDKSREG 351
            .:||.:|||||||||.|||.||..||:.:.........|.  ::.|:||||:|::||||.||...
  Fly   540 AVMNTLYKERFPKATQQMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAK 604

Zfish   352 LITSRYFYELQENLEKLHQDAHERSESGEVTFVTQLVKKLMIIIARPARLLECLEFDPEEFYHLL 416
            ||||:|||||.||||:|..:..|:|...... :..::|||::||:|||||||||||||:|||.||
  Fly   605 LITSQYFYELSENLERLLVETKEKSPEAAAE-LNGVIKKLLLIISRPARLLECLEFDPQEFYELL 668

Zfish   417 EAAEGHAKEGQGIKSDIPRYIISQLGLTRDPLEEM------------------------------ 451
            ||||||||....||:|||:|||.:|||.|||:.|:
  Fly   669 EAAEGHAKAMPVIKADIPQYIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLL 733

Zfish   452 --------AQLSS-------YDSGN--------PETPETETDSTDSRGATVQPLQPQP------- 486
                    .||||       .|||:        |:||....|:..|....:..:..:.
  Fly   734 NSPLTSAAKQLSSLALDAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAV 798

Zfish   487 --------------------------QPQPKTKTPREEDFETIKLISNGAYGAVFLVRHKETRQR 525
                                      ..||   :|:|.||:.:|||||||||||:||:||.||||
  Fly   799 GGGSSSKVAGAEGITGGSAATATGSGAQQP---SPQENDFDIVKLISNGAYGAVYLVKHKTTRQR 860

Zfish   526 FAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLK 590
            ||||||||.|||||||::|.|.|||||:||:|||||||:|||||::|||:||||||||||.||||
  Fly   861 FAMKKINKNNLILRNQVEQVFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLK 925

Zfish   591 HIGALPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHVKLTDFGLSKIGLMSLTTN 655
            :||.||.||||.||||||||:||||:||||||||||||||||::||:|||||||||:|||||.||
  Fly   926 NIGPLPADMARFYFAETVLAVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATN 990

Zfish   656 LYEGHIEKDTREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGVILYEFLVGCAPFFGDTPEE 720
            ||||:|:.:||:|.||||.|||||||||||||||||||||||:||:||||||:||.||||:|.||
  Fly   991 LYEGYIDSETRQFSDKQVYGTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEE 1055

Zfish   721 LFGQVISDEIIWPEGDE-ALPPDAQDLISKLLRQNPLERLGTGS-AFEVKQHRFFTDLDWNSLLR 783
            ||...::|:|.||:.:: .:..:|:|:||:||:|||.:||||.| |.|:|:|.:|..:|||||||
  Fly  1056 LFAHTVNDDIEWPDSEDWPVQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLR 1120

Zfish   784 QKAEFIPQLESEDDTSYFDTRSDRYHH-VDSEEEDDTNDDDHLEIRQFSSCSPRFSKVYSSMER- 846
            |||||:|||..:|||||||||.|||:| :..|:.|||  ||......|:|.:|::.|.:.|..|
  Fly  1121 QKAEFVPQLSHDDDTSYFDTRMDRYNHDLGGEDTDDT--DDTPVFGSFNSYTPQYRKQHYSWSRH 1183

Zfish   847 ---LSLHEEKRTPPPTKRSLSEEGGERIDSLSGLKSRDRSWLVGSPEILRKRLSVSESSHTESDS 908
               .|....|.|.||...||.....|...:..|..|      .|:...|:..:.....|.:.|.|
  Fly  1184 ATPTSTDGAKPTGPPPLSSLPSRAQETPAATVGATS------TGALPKLKSGMGSGSGSGSGSGS 1242

Zfish   909 SPPLTVRRRCCSAIIEMPRFAISSEEDSCVGSRKTPVRGPRGDDLPQAIPELPV--ERELR---- 967
            ..  .......:..:..|:........||:   |.| ..|..|.||:.:..:.:  :.|||
  Fly  1243 GS--ASHDGVVNKFLNTPQLRKLDLSSSCL---KVP-STPDADYLPELLHNVTIGNDAELRMLKH 1301

Zfish   968 -------------------------LDESPTTPGSTSSQISQS----TLTPGS------------ 991
                                     :..:|.||..|.:|.:.:    |.|.||
  Fly  1302 YLQQPNPGATQRMQQRHSMPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTD 1366

Zfish   992 ----------------SGDVLDR---------ASRYSAEVSENSTPRAISDLAARRARHRLLSGD 1031
                            :.|:|.|         .|..|:.....:.||..|.||.:. :.:.:.|.
  Fly  1367 SDDFSPQINRKRKGVCARDILPRFSISIEDETISAGSSSTENMNLPREQSPLALQH-QPKSMDGS 1430

Zfish  1032 TD-----KHTSRPLSKVIKSASATTLSLMIPADHHGASPLA-------SPMSPHSLSSNPSSRDS 1084
            |.     .|.||   .::|||||..||||...|:   |.||       ||....:.||..||||:
  Fly  1431 TSGSSVKHHRSR---SIVKSASALGLSLMTSLDN---SQLAAQLCGIQSPGGGGNGSSTASSRDT 1489

Zfish  1085 SPSRDLSPAVCSVKPAIIIHRAGKKYGFTLRAIRVYMGDTDIYTVHHMVWHVEDGGPAHEAGLRE 1149
            ||.|:|||.|.::||.|||.|..:.:|||:..||||.||||.||:||:|..|::|.||.|||||.
  Fly  1490 SPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRP 1554

Zfish  1150 GDLITHVNGEPVHGLVHTEVVELILKSGSKVSISATPFENTSIKVGPARKTSYKSKMARR--NKR 1212
            .|||||||||.|.||.||:|::|:|..|..|::.|||.|:|||:.|..::...:||:|::  |::
  Fly  1555 ADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQ 1619

Zfish  1213 TK-TREGQDSKKRNSLFRKITKQATLLHTSRSLSSLNRSVSSGESVPGSPT--HMSP--RSPTQG 1272
            .| |:...|.|::.||||:|        :|:..::..:..|:|.|.|.:|:  ::||  .|....
  Fly  1620 KKQTKREHDKKRKTSLFRRI--------SSKRANAEMQQYSAGTSSPTTPSARNLSPLDSSYHSS 1676

Zfish  1273 CRSTPDSAHSVGGNSSQSSSPSSSVPNSPASS--------------------------------- 1304
            |      ..|...:||||:|||||.||:|..|
  Fly  1677 C------CQSAANSSSQSTSPSSSSPNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLV 1735

Zfish  1305 ----------------GQI-------------RPSSLHGLAPKLQR---------QYRSP----- 1326
                            |.:             |||:||||..||..         ...:|
  Fly  1736 LLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLK 1800

Zfish  1327 ------------RRKSAGNIPLSPLARTPSPTPQSTSPQRSPSPLPSHGLITSSIGQSFPVKLHS 1379
                        ||||.|:||||||||||||:|..:||.|||||| :..|:....|.|...:.:|
  Fly  1801 TLHTTNNNSLPNRRKSVGHIPLSPLARTPSPSPLPSSPTRSPSPL-AFPLVGHQPGASNTTQSYS 1864

Zfish  1380 S----PPLVRQI---------SRPKSADPPRSPLLKRVQSAEKLAASLSSSSSSPSPSSAADKKL 1431
            .    |.|...:         :|.|||: |.||||:|..|.::|           .|.||..|..
  Fly  1865 PGSTLPTLQTAVNANTKKAGFARTKSAE-PSSPLLRRALSPDRL-----------HPRSAETKIS 1917

Zfish  1432 PVGASRKHSLDTSHSEFKKEMLQRDPSLQSLQESASETLMGGRVSPAEKGSLQKSSVRKLGRQEG 1496
            |:..|..               .:.|:.|.:..:...:..||..|.|....|...||:
  Fly  1918 PLCCSPP---------------IKQPTHQRVVTTTWRSTPGGSASGAGGAVLGAPSVQ------- 1960

Zfish  1497 PESGTGTLGLVPGKSKLKDKLSAIRAERRESLQKQDAIHEVDSSEDETDEGSEDSQDGRRTCYAP 1561
                  .|.|||..|              |..|:|.|:..|.|:   |..|::
  Fly  1961 ------PLQLVPAAS--------------EESQRQTAMATVVST---TAAGTD------------ 1990

Zfish  1562 PSHVLRPTTVMASPHTIRMGPAAPPTLGLFPSTVAPPCSPQLIRGLQIQNQSTTQSQTQTSTSQP 1626
            ||.....|.....|..........||.....|:|:....|.:   .:.....::.|.|||.....
  Fly  1991 PSATAVVTLANCEPLPRIAEEKDSPTSTQDSSSVSEGFMPAI---EEFAEGESSSSPTQTLEKPT 2052

Zfish  1627 AQAAVKPPEQKPITSVKDSSSTIIDDSKKQSQAQDIQSRPSPHQPSPLSSTFSTQGSAFTSVSKD 1691
            ...|.:.||.:|           ...|||..|.
  Fly  2053 KVKATEQPEMEP-----------AGKSKKVDQG-------------------------------- 2074

Zfish  1692 PFVKPTTPPLDPRRTPKMSEPRSKTSG-RTDSSTTSGVARDTPVATTPTGGITKEMKEADNRRQA 1755
               |.|||     .||| ::|.:  || :|..:||...:....::|.|         ..|.....
  Fly  2075 ---KTTTP-----GTPK-TKPHN--SGCKTSMTTTKPASPSVTISTAP---------RKDTSAVT 2119

Zfish  1756 AAAAAASAAAATTSAS 1771
            ...::.|..:|.|||:
  Fly  2120 GGGSSGSGGSAATSAA 2135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mast2	XP_009300769.1	DUF1908	169..450	CDD:286070	159/362 (44%)
		STKc_MAST	499..778	CDD:270760	205/280 (73%)
		S_TKc	500..773	CDD:214567	203/274 (74%)
		PDZ_signaling	1101..1182	CDD:238492	48/80 (60%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	159/362 (44%)
		STKc_MAST	834..1115	CDD:270760	205/280 (73%)
		S_TKc	835..1110	CDD:214567	203/274 (74%)
		PDZ_signaling	1506..1587	CDD:238492	48/80 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589137
Domainoid	1	1.000	440	1.000	Domainoid score	I524
eggNOG	1	0.900	-	-		E1_KOG0606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1041	1.000	Inparanoid score	I260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm24417
orthoMCL	1	0.900	-	-		OOG6_100724
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.850