DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment si:dkey-33c12.12 and NMA111

DIOPT Version :9

Sequence 1:	NP_001082916.2	Gene:	si:dkey-33c12.12 / 100000024	ZFINID:	ZDB-GENE-081028-30	Length:	214	Species:	Danio rerio
Sequence 2:	NP_014276.1	Gene:	NMA111 / 855600	SGDID:	S000005067	Length:	997	Species:	Saccharomyces cerevisiae

Alignment Length:	200	Identity:	51/200 - (25%)
Similarity:	90/200 - (45%)	Gaps:	23/200 - (11%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MGSPFSLKNTITSGIISSAQRGSKELG---LSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGIN 62
            :|:....|.:|.:|.||...|.:.|.|   .::.|.:|||..|:...|:||.|::|:||..:.:.
Yeast   187 VGNDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQ 251

Zfish    63 TMKVT-AGISFAIPLGRV-RLFLDRSADK-------QKSWFGESGWKRRYIGVMMLTLTPSIIEE 118
            ....| |...|.:||.|: |..:....:|       |..|.     .:.|.....|.||.....|
Yeast   252 AGGSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWL-----LKPYDECRRLGLTSERESE 311

Zfish   119 LRMRDPSFPDISHGVLIHRVIVGSPANRAGMKPGDVIIEINGVKVNTSEEI--YNAVRTSESLNV 181
            .|.:   ||: :.|:|:...::........:|.||.:|.|||..:::..::  .......:.:.:
Yeast   312 ARAK---FPE-NIGLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQL 372

Zfish   182 VVRRG 186
            |::||
Yeast   373 VIQRG 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
si:dkey-33c12.12	NP_001082916.2	Trypsin_2	<1..61	CDD:290102	21/62 (34%)
si:dkey-33c12.12	NP_001082916.2	PDZ_serine_protease	102..186	CDD:238487	18/85 (21%)
NMA111	NP_014276.1	DegQ	48..391	CDD:223343	50/199 (25%)
		PDZ_1	392..469	CDD:372324
		DegQ	543..870	CDD:223343
		PDZ	<810..862	CDD:412172
		PDZ	869..944	CDD:412172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I3096
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770