DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment si:dkey-33c12.12 and Htra2

DIOPT Version :9

Sequence 1:	NP_001082916.2	Gene:	si:dkey-33c12.12 / 100000024	ZFINID:	ZDB-GENE-081028-30	Length:	214	Species:	Danio rerio
Sequence 2:	NP_062726.3	Gene:	Htra2 / 64704	MGIID:	1928676	Length:	458	Species:	Mus musculus

Alignment Length:	200	Identity:	134/200 - (67%)
Similarity:	168/200 - (84%)	Gaps:	1/200 - (0%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MGSPFSLKNTITSGIISSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMK 65
            |||||:|:|||||||:|||||.:::|||..:|::||||||.||||||||||:||||||||:||||
Mouse   260 MGSPFALQNTITSGIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMK 324

Zfish    66 VTAGISFAIPLGRVRLFLDRSADKQKSWFGESGWKRRYIGVMMLTLTPSIIEELRMRDPSFPDIS 130
            ||||||||||..|:|.||.| .:|:.||||.||.:|||||||||||||||:.||::|:|||||:.
Mouse   325 VTAGISFAIPSDRLREFLHR-GEKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFPDVQ 388

Zfish   131 HGVLIHRVIVGSPANRAGMKPGDVIIEINGVKVNTSEEIYNAVRTSESLNVVVRRGADLLMLHMT 195
            ||||||:||:||||:|||::|||||:.|.......:|::|.||||...|.|.:|||::.|.|::|
Mouse   389 HGVLIHKVILGSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQLAVRIRRGSETLTLYVT 453

Zfish   196 PESTE 200
            ||.||
Mouse   454 PEVTE 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
si:dkey-33c12.12	NP_001082916.2	Trypsin_2	<1..61	CDD:290102	45/59 (76%)
si:dkey-33c12.12	NP_001082916.2	PDZ_serine_protease	102..186	CDD:238487	52/83 (63%)
Htra2	NP_062726.3	DegQ	125..454	CDD:223343	129/194 (66%)
		IAP-binding motif. /evidence=ECO:0000250	134..137
		Serine protease	166..342		62/81 (77%)
		Trypsin_2	182..320	CDD:290102	45/59 (76%)
		PDZ_serine_protease	360..452	CDD:238487	56/91 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C193130088
Domainoid	1	1.000	209	1.000	Domainoid score	I12021
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	463	1.000	Inparanoid score	I6935
OMA	1	1.010	-	-		QHG43674
OrthoDB	1	1.010	-	-		D210946at7742
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm30105
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	LDO	PTHR22939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770