DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment si:dkey-33c12.12 and Htra2

DIOPT Version :9

Sequence 1:	NP_001082916.2	Gene:	si:dkey-33c12.12 / 100000024	ZFINID:	ZDB-GENE-081028-30	Length:	214	Species:	Danio rerio
Sequence 2:	NP_001100069.1	Gene:	Htra2 / 297376	RGDID:	1308906	Length:	458	Species:	Rattus norvegicus

Alignment Length:	200	Identity:	133/200 - (66%)
Similarity:	167/200 - (83%)	Gaps:	1/200 - (0%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MGSPFSLKNTITSGIISSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMK 65
            |||||:|:|||||||:|||||.:::|||..:|::||||||.||||||||||:||||||||:||||
  Rat   260 MGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMK 324

Zfish    66 VTAGISFAIPLGRVRLFLDRSADKQKSWFGESGWKRRYIGVMMLTLTPSIIEELRMRDPSFPDIS 130
            ||||||||||..|:|.||.| .:|:.||||.||.:|||||||||||||||:.||::|:|||||:.
  Rat   325 VTAGISFAIPSDRLREFLHR-GEKKNSWFGISGSQRRYIGVMMLTLTPSILAELQLREPSFPDVQ 388

Zfish   131 HGVLIHRVIVGSPANRAGMKPGDVIIEINGVKVNTSEEIYNAVRTSESLNVVVRRGADLLMLHMT 195
            ||||||:||:||||:|||::|.|||:.|....:..:|::|.||||...|.|.:|||.:.|.|::|
  Rat   389 HGVLIHKVILGSPAHRAGLRPADVILAIGEKMIQNAEDVYEAVRTQSQLAVRIRRGPETLTLYVT 453

Zfish   196 PESTE 200
            ||.||
  Rat   454 PEVTE 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
si:dkey-33c12.12	NP_001082916.2	Trypsin_2	<1..61	CDD:290102	45/59 (76%)
si:dkey-33c12.12	NP_001082916.2	PDZ_serine_protease	102..186	CDD:238487	51/83 (61%)
Htra2	NP_001100069.1	DegQ	140..454	CDD:223343	128/194 (66%)
		Trypsin_2	182..320	CDD:290102	45/59 (76%)
		PDZ_serine_protease	360..452	CDD:238487	55/91 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194890110
Domainoid	1	1.000	210	1.000	Domainoid score	I11496
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	461	1.000	Inparanoid score	I6703
OMA	1	1.010	-	-		QHG43674
OrthoDB	1	1.010	-	-		D210946at7742
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm32365
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	LDO	PTHR22939
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770