DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AKT3 and JIL-1

DIOPT Version :9

Sequence 1:	NP_001357003.1	Gene:	AKT3 / 10000	HGNCID:	393	Length:	479	Species:	Homo sapiens
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	146/392 - (37%)
Similarity:	218/392 - (55%)	Gaps:	34/392 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   118 NCSPTSQIDNIGEEEMDASTT--------HHKRKTMNDFDYLKLLGKGTFGKVILVREKA---SG 171
            |.:|....:...:.:::|.|.        ..:..::|||..:::||.|.:|:|.|||:..   :|
  Fly   223 NSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAG 287

Human   172 KYYAMKILKKEVIIAKDEVA-HTLTESRVLKN-TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELF 234
            |.||||:|.|..::.|.:.| ||.||..||:. .|:|||.||.|:||:..:|..|:::.||||||
  Fly   288 KLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELF 352

Human   235 FHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD 299
            .||.....|.|.|.|.|.||:|.||:.||...|:|||:||||::||.:|||.::||||.|  |..
  Fly   353 THLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSK--ILT 415

Human   300 AAT---MKTFCGTPEYLAPEVLEDNDYGR--AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLF 355
            |..   ..:||||.||:|||::.....|.  |||||.:||:.:|::.|..||...|    ..::.
  Fly   416 AENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEIS 480

Human   356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP 420
            ..|..|....|.:.|::|:..:..:|.|:|.:||||...||.||..|.||:|:|||::..|:...
  Fly   481 RRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRTKRRKA 545

Human   421 PFKPQVTSETDTRYFDEEFTAQT----ITITPPEK------YDEDGMDCMDNERRPHFPQFSYSA 475
            |:||.:|:|.|.:.|..|||.|.    ....||.:      |.....:.::..||.:..:..|..
  Fly   546 PYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPSRIRLFRGYTYVAPEHLEQMRRDNHCEIQYFN 610

Human   476 SG 477
            :|
  Fly   611 TG 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AKT3	NP_001357003.1	PH_PKB	4..110	CDD:269947
		STKc_PKB_gamma	132..479	CDD:270745	144/378 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..479		4/20 (20%)
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	115/270 (43%)
		STKc_MSK_N	266..533	CDD:270735	116/268 (43%)
		S_TK_X	532..591	CDD:214529	19/58 (33%)
		S_TKc	632..886	CDD:214567
		PKc_like	632..885	CDD:304357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910