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DRSC
>> Reagents
>> RNAi Sub-Libraries
Sub-Libraries for RNAi Knockdown of Functionally Related Gene Sets
In response to community demand, we have constructed dsRNA sub-libraries that target genes grouped by biological and/or biochemical function.
Features include:
- Rapid screening (fewer plates to screen than with the full genomic collection)
- Curated gene lists drawn from the published literature, known and predicted functions, and shared by experts in their fields
- Deeper coverage—multiple unique dsRNA amplicons per gene
- Adheres to current rules for minimizing off-target effects
- Available for on-site screening or in experiment-ready 384-well assay plates for screening at your institution (contact the Director for details)
Currently Available Sub-Libraries
| Library |
Gene Set |
# of Genes |
Ave. # of amplicons per gene |
# of Assay Plates |
| DRSC KP |
Kinases & Phosphatases |
468 |
3 |
8 |
| DRSC TRXN |
Transcription Factors |
993 |
2 |
9 |
More on the Currently Available Sub-Libraries
Drosophila Kinase/Phosphatase RNAi Sub-Library (DRSC KP). This sub-library targets the complete set of Drosophila genes that encode proteins with kinase or phosphatase activity. Approximately three amplicon per gene coverage. 468 genes. Eight assay plates.
Drosophila Transcription Factor RNAi Sub-Library (DRSC TRXN). This sub-library targets the complete set of Drosophila genes that encode transcription factors. Approximately two amplicon per gene coverage. 993 genes. Nine assay plates.
In Production
Drosophila Ubiquitin-Related Genes RNAi Sub-Library (NYU-DRSC UBIQ). This sub-library targets genes involved in ubiquitination. The sub-set is being produced by researchers at New York University in collaboration with the DRSC.
What next? New sub-sets are planned based on community input. Please contact the Director with ideas.
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